Catherine Mansfield is a postdoctoral research associate in the Myocardial Function section of the National Heart and Lung Institute. She currently works as part of the BHF Centre for Regenerative Medicine in the laboratories of Dr Alex Lyon, Dr Cesare Terracciano and Professor Sian Harding. Her current research focusses on assessing the electrophysiological impact of stem cell delivery and engraftment to the failing heart.
Catherine graduated from the University of Sheffield in 2007 with a BSc in Physiology and Pharmacology. She then moved to Imperial College to study for an MRes in Integrative Mammalian Biology where she completed a research project supervised by Professor Sian Harding and Dr Alex Lyon developing an in vivo model of Takotsubo cardiomyopathy - an acute form of heart failure induced by sudden emotional or physical stress.
In 2012 she completed her PhD in the laboratory of Professor Mike Ferenczi at the National Heart and Lung Institute. Her thesis focussed on the mechanics and energetics of cardiac muscle contraction and the mechanism of the Frank-Starling Law of the heart.
She joined the Myocardial Genetics group of Professor Ralph Knöll as a postdoctoral research associate in 2012 where her research focused on investigating the mechanisms of mechanosensation and mechanotransduction in cardiac muscle.
et al., 2020, Humoral factors in serum of rats with chronic heart failure induce cardiomyocyte hypertrophy and reduce viability., Clinical Medicine (london, England), Vol:20, ISSN:1470-2118, Pages:s107-s107
et al., 2020, Ventricular fibrillation mechanism and global fibrillatory organisation are determined by gap junction coupling and fibrosis pattern, Cardiovascular Research, ISSN:0008-6363
et al., 2020, beta(3)-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes, Elife, Vol:9, ISSN:2050-084X, Pages:1-15
et al., 2019, Interventricular differences in action potential duration restitution contribute to dissimilar ventricular rhythms in ex vivo perfused hearts, Frontiers in Cardiovascular Medicine, Vol:6, ISSN:2297-055X
et al., 2018, Auxetic cardiac patches with tunable mechanical and conductive properties toward treating myocardial infarction, Advanced Functional Materials, Vol:28, ISSN:1616-301X