Imperial College London
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Charlie Whittaker

Faculty of Medicine, School of Public Health

Research Fellow
 
 
 
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Contact

 

charles.whittaker16

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Buss:2022:10.3390/vaccines10091437,
author = {Buss, L and Prete, CA and Whittaker, C and Salomon, T and Oikawa, MK and Pereira, RHM and Moura, ICG and Delerino, L and Franca, RFO and Miyajima, F and Mendrone, Jr A and Almeida-Neto, C and Salles, NA and Ferreira, SC and Fladzinski, KA and de, Souza LM and Schier, LK and Inoue, PM and Xabregas, LA and Crispim, MAE and Fraiji, N and Carlos, LMB and Pessoa, V and Ribeiro, MA and de, Souza RE and Cavalcante, AF and Valenca, MIB and da, Silva M and Lopes, E and Filho, LA and Mateos, SOG and Nunes, GT and Schlesinger, D and Nunes, da Silva SM and Silva-Junior, AL and Castro, MC and Nascimento, VH and Dye, C and Busch, MP and Faria, NR and Sabino, EC},
doi = {10.3390/vaccines10091437},
journal = {Vaccines},
pages = {1--11},
title = {Predicting SARS-CoV-2 variant spread in a completely seropositive population using semi-quantitative antibody measurements in blood donors},
url = {http://dx.doi.org/10.3390/vaccines10091437},
volume = {10},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - SARS-CoV-2 serologic surveys estimate the proportion of the population with antibodies against historical variants, which nears 100% in many settings. New approaches are required to fully exploit serosurvey data. Using a SARS-CoV-2 anti-Spike (S) protein chemiluminescent microparticle assay, we attained a semi-quantitative measurement of population IgG titers in serial cross-sectional monthly samples of blood donations across seven Brazilian state capitals (March 2021–November 2021). Using an ecological analysis, we assessed the contributions of prior attack rate and vaccination to antibody titer. We compared anti-S titer across the seven cities during the growth phase of the Delta variant and used this to predict the resulting age-standardized incidence of severe COVID-19 cases. We tested ~780 samples per month, per location. Seroprevalence rose to >95% across all seven capitals by November 2021. Driven by vaccination, mean antibody titer increased 16-fold over the study, with the greatest increases occurring in cities with the highest prior attack rates. Mean anti-S IgG was strongly correlated (adjusted R2 = 0.89) with the number of severe cases caused by Delta. Semi-quantitative anti-S antibody titers are informative about prior exposure and vaccination coverage and may also indicate the potential impact of future SARS-CoV-2 variants.
AU  - Buss,L
AU  - Prete,CA
AU  - Whittaker,C
AU  - Salomon,T
AU  - Oikawa,MK
AU  - Pereira,RHM
AU  - Moura,ICG
AU  - Delerino,L
AU  - Franca,RFO
AU  - Miyajima,F
AU  - Mendrone,Jr A
AU  - Almeida-Neto,C
AU  - Salles,NA
AU  - Ferreira,SC
AU  - Fladzinski,KA
AU  - de,Souza LM
AU  - Schier,LK
AU  - Inoue,PM
AU  - Xabregas,LA
AU  - Crispim,MAE
AU  - Fraiji,N
AU  - Carlos,LMB
AU  - Pessoa,V
AU  - Ribeiro,MA
AU  - de,Souza RE
AU  - Cavalcante,AF
AU  - Valenca,MIB
AU  - da,Silva M
AU  - Lopes,E
AU  - Filho,LA
AU  - Mateos,SOG
AU  - Nunes,GT
AU  - Schlesinger,D
AU  - Nunes,da Silva SM
AU  - Silva-Junior,AL
AU  - Castro,MC
AU  - Nascimento,VH
AU  - Dye,C
AU  - Busch,MP
AU  - Faria,NR
AU  - Sabino,EC
DO  - 10.3390/vaccines10091437
EP  - 11
PY  - 2022///
SN  - 2076-393X
SP  - 1
TI  - Predicting SARS-CoV-2 variant spread in a completely seropositive population using semi-quantitative antibody measurements in blood donors
T2  - Vaccines
UR  - http://dx.doi.org/10.3390/vaccines10091437
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000857149600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.mdpi.com/2076-393X/10/9/1437
UR  - http://hdl.handle.net/10044/1/101650
VL  - 10
ER  -
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