Imperial College London
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Charlie Whittaker

Faculty of Medicine, School of Public Health

Research Fellow
 
 
 
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Contact

 

charles.whittaker16

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{de:2023:10.1016/S2666-5247(23)00033-2,
author = {de, Souza WM and de, Lima STS and Simões, Mello LM and Candido, DS and Buss, L and Whittaker, C and Claro, IM and Chandradeva, N and Granja, F and de, Jesus R and Lemos, PS and Toledo-Teixeira, DA and Barbosa, PP and Firmino, ACL and Amorim, MR and Duarte, LMF and Pessoa, IB and Forato, J and Vasconcelos, IL and Maximo, ACBM and Araújo, ELL and Perdigão, Mello L and Sabino, EC and Proença-Módena, JL and Faria, NR and Weaver, SC},
doi = {10.1016/S2666-5247(23)00033-2},
journal = {The Lancet Microbe},
pages = {e319--e329},
title = {Spatiotemporal dynamics and recurrence of chikungunya virus in Brazil: an epidemiological study},
url = {http://dx.doi.org/10.1016/S2666-5247(23)00033-2},
volume = {4},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Chikungunya virus (CHIKV) is an Aedes mosquito-borne virus that has caused large epidemics linked to acute, chronic, and severe clinical outcomes. Currently, Brazil has the highest number of chikungunya cases in the Americas. We aimed to investigate the spatiotemporal dynamics and recurrence pattern of chikungunya in Brazil since its introduction in 2013. METHODS: In this epidemiological study, we used CHIKV genomic sequencing data, CHIKV vector information, and aggregate clinical data on chikungunya cases from Brazil. The genomic data comprised 241 Brazilian CHIKV genome sequences from GenBank (n=180) and the 2022 CHIKV outbreak in Ceará state (n=61). The vector data (Breteau index and House index) were obtained from the Brazilian Ministry of Health for all 184 municipalities in Ceará state and 116 municipalities in Tocantins state in 2022. Epidemiological data on laboratory-confirmed cases of chikungunya between 2013 and 2022 were obtained from the Brazilian Ministry of Health and Laboratory of Public Health of Ceará. We assessed the spatiotemporal dynamics of chikungunya in Brazil via time series, mapping, age-sex distribution, cumulative case-fatality, linear correlation, logistic regression, and phylogenetic analyses. FINDINGS: Between March 3, 2013, and June 4, 2022, 253 545 laboratory-confirmed chikungunya cases were reported in 3316 (59·5%) of 5570 municipalities, mainly distributed in seven epidemic waves from 2016 to 2022. To date, Ceará in the northeast has been the most affected state, with 77 418 cases during the two largest epidemic waves in 2016 and 2017 and the third wave in 2022. From 2016 to 2022 in Ceará, the odds of being CHIKV-positive were higher in females than in males (odds ratio 0·87, 95% CI 0·85-0·89, p<0·0001), and the cumulative case-fatality ratio was 1·3 deaths per 1000 cases. Chikungunya recurrences in the states of Ceará
AU  - de,Souza WM
AU  - de,Lima STS
AU  - Simões,Mello LM
AU  - Candido,DS
AU  - Buss,L
AU  - Whittaker,C
AU  - Claro,IM
AU  - Chandradeva,N
AU  - Granja,F
AU  - de,Jesus R
AU  - Lemos,PS
AU  - Toledo-Teixeira,DA
AU  - Barbosa,PP
AU  - Firmino,ACL
AU  - Amorim,MR
AU  - Duarte,LMF
AU  - Pessoa,IB
AU  - Forato,J
AU  - Vasconcelos,IL
AU  - Maximo,ACBM
AU  - Araújo,ELL
AU  - Perdigão,Mello L
AU  - Sabino,EC
AU  - Proença-Módena,JL
AU  - Faria,NR
AU  - Weaver,SC
DO  - 10.1016/S2666-5247(23)00033-2
EP  - 329
PY  - 2023///
SN  - 2666-5247
SP  - 319
TI  - Spatiotemporal dynamics and recurrence of chikungunya virus in Brazil: an epidemiological study
T2  - The Lancet Microbe
UR  - http://dx.doi.org/10.1016/S2666-5247(23)00033-2
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37031687
UR  - http://hdl.handle.net/10044/1/103820
VL  - 4
ER  -
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