Imperial College London
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DrChloeBloom

Faculty of Medicine, National Heart & Lung Institute

Clinical Senior Lecturer in Respiratory Epidemiology
 
 
 
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chloe.bloom06

 
 
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Location

 

Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bloom:2021:10.1016/S2213-2600(21)00013-8,
author = {Bloom, CI and Drake, TM and Docherty, AB and Lipworth, BJ and Johnston, SL and Nguyen-Van-Tam, JS and Carson, G and Dunning, J and Harrison, EM and Baillie, JK and Semple, MG and Cullinan, P and Openshaw, PJM and Alex, B and Bach, B and Barclay, WS and Bogaert, D and Chand, M and Cooke, GS and Filipe, AD and Fletcher, T and Green, CA and Harrison, EM and Hiscox, JA and Ho, AY and Horby, PW and Ijaz, S and Khoo, S and Klenerman, P and Law, A and Lim, WS and Mentzer, AJ and Merson, L and Meynert, AM and Noursadeghi, M and Moore, SC and Palmarini, M and Paxton, WA and Pollakis, G and Price, N and Rambaut, A and Robertson, DL and Russell, CD and Sancho-Shimizu, V and Scott, JT and Silva, TD and Sigfrid, L and Solomon, T and Sriskandan, S and Stuart, D and Summers, C and Tedder, RS and Thomson, EC and Thompson, AAR and Thwaites, RS and Turtle, LCW and Zambon, M and Hardwick, H and Donohue, C and Lyons, R and Griffiths, F and Oosthuyzen, W and Norman, L and Pius, R and Fairfield, CJ and Knig},
doi = {10.1016/S2213-2600(21)00013-8},
journal = {The Lancet Respiratory Medicine},
pages = {699--711},
title = {Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK},
url = {http://dx.doi.org/10.1016/S2213-2600(21)00013-8},
volume = {9},
year = {2021}
}
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TY  - JOUR
AB  - BackgroundStudies of patients admitted to hospital with COVID-19 have found varying mortality outcomes associated with underlying respiratory conditions and inhaled corticosteroid use. Using data from a national, multicentre, prospective cohort, we aimed to characterise people with COVID-19 admitted to hospital with underlying respiratory disease, assess the level of care received, measure in-hospital mortality, and examine the effect of inhaled corticosteroid use.MethodsWe analysed data from the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) WHO Clinical Characterisation Protocol UK (CCP-UK) study. All patients admitted to hospital with COVID-19 across England, Scotland, and Wales between Jan 17 and Aug 3, 2020, were eligible for inclusion in this analysis. Patients with asthma, chronic pulmonary disease, or both, were identified and stratified by age (<16 years, 16–49 years, and ≥50 years). In-hospital mortality was measured by use of multilevel Cox proportional hazards, adjusting for demographics, comorbidities, and medications (inhaled corticosteroids, short-acting β-agonists [SABAs], and long-acting β-agonists [LABAs]). Patients with asthma who were taking an inhaled corticosteroid plus LABA plus another maintenance asthma medication were considered to have severe asthma.Findings75 463 patients from 258 participating health-care facilities were included in this analysis: 860 patients younger than 16 years (74 [8·6%] with asthma), 8950 patients aged 16–49 years (1867 [20·9%] with asthma), and 65 653 patients aged 50 years and older (5918 [9·0%] with asthma, 10 266 [15·6%] with chronic pulmonary disease, and 2071 [3·2%] with both asthma and chronic pulmonary disease). Patients with asthma were significantly more likely than those without asthma to receive critical care (patients aged 16–49 years: adjusted odds ratio [OR] 1·20 [95% CI
AU  - Bloom,CI
AU  - Drake,TM
AU  - Docherty,AB
AU  - Lipworth,BJ
AU  - Johnston,SL
AU  - Nguyen-Van-Tam,JS
AU  - Carson,G
AU  - Dunning,J
AU  - Harrison,EM
AU  - Baillie,JK
AU  - Semple,MG
AU  - Cullinan,P
AU  - Openshaw,PJM
AU  - Alex,B
AU  - Bach,B
AU  - Barclay,WS
AU  - Bogaert,D
AU  - Chand,M
AU  - Cooke,GS
AU  - Filipe,AD
AU  - Fletcher,T
AU  - Green,CA
AU  - Harrison,EM
AU  - Hiscox,JA
AU  - Ho,AY
AU  - Horby,PW
AU  - Ijaz,S
AU  - Khoo,S
AU  - Klenerman,P
AU  - Law,A
AU  - Lim,WS
AU  - Mentzer,AJ
AU  - Merson,L
AU  - Meynert,AM
AU  - Noursadeghi,M
AU  - Moore,SC
AU  - Palmarini,M
AU  - Paxton,WA
AU  - Pollakis,G
AU  - Price,N
AU  - Rambaut,A
AU  - Robertson,DL
AU  - Russell,CD
AU  - Sancho-Shimizu,V
AU  - Scott,JT
AU  - Silva,TD
AU  - Sigfrid,L
AU  - Solomon,T
AU  - Sriskandan,S
AU  - Stuart,D
AU  - Summers,C
AU  - Tedder,RS
AU  - Thomson,EC
AU  - Thompson,AAR
AU  - Thwaites,RS
AU  - Turtle,LCW
AU  - Zambon,M
AU  - Hardwick,H
AU  - Donohue,C
AU  - Lyons,R
AU  - Griffiths,F
AU  - Oosthuyzen,W
AU  - Norman,L
AU  - Pius,R
AU  - Fairfield,CJ
AU  - Knight,SR
AU  - Mclean,KA
AU  - Murphy,D
AU  - Shaw,CA
AU  - Dalton,J
AU  - Girvan,M
AU  - Saviciute,E
AU  - Roberts,S
AU  - Harrison,J
AU  - Marsh,L
AU  - Connor,M
AU  - Halpin,S
AU  - Jackson,C
AU  - Gamble,C
AU  - Leeming,G
AU  - Law,A
AU  - Wham,M
AU  - Clohisey,S
AU  - Hendry,R
AU  - Scott-Brown,J
AU  - Greenhalf,W
AU  - Shaw,V
AU  - McDonald,S
AU  - Keating,S
AU  - Ahmed,KA
AU  - Armstrong,JA
AU  - Ashworth,M
AU  - Asiimwe,IG
AU  - Bakshi,S
AU  - Barlow,SL
AU  - Booth,L
AU  - Brennan,B
AU  - Bullock,K
AU  - Catterall,BWA
AU  - Clark,JJ
AU  - Clarke,EA
AU  - Cole,S
AU  - Cooper,L
AU  - Cox,H
AU  - Davis,C
AU  - Dincarslan,O
AU  - Dunn,C
AU  - Dyer,P
AU  - Elliott,A
AU  - Evans,A
AU  - Finch,L
AU  - Fisher,LWS
AU  - Foster,T
AU  - Garcia-Dorival,I
AU  - Greenhalf,W
AU  - Gunning,P
AU  - Hartley,C
AU  - Jensen,RL
AU  - Jones,CB
AU  - Jones,TR
AU  - Khandaker,S
AU  - King,K
AU  - Kiy,RT
AU  - Koukorava,C
AU  - Lake,A
AU  - Lant,S
AU  - Latawiec,D
AU  - Lavelle-Langham,L
AU  - Lefteri,D
AU  - Lett,L
AU  - Livoti,LA
AU  - Mancini,M
AU  - McDonald,S
AU  - McEvoy,L
AU  - McLauchlan,J
AU  - Metelmann,S
AU  - Miah,NS
AU  - Middleton,J
AU  - Mitchell,J
AU  - Moore,SC
AU  - Murphy,EG
AU  - Penrice-Randal,R
AU  - Pilgrim,J
AU  - Prince,T
AU  - Reynolds,W
AU  - Ridley,PM
AU  - Sales,D
AU  - Shaw,VE
AU  - Shears,RK
AU  - Small,B
AU  - Subramaniam,KS
AU  - Szemiel,A
AU  - Taggart,A
AU  - Tanianis-Hughes,J
AU  - Thomas,J
AU  - Trochu,E
AU  - Tonder,LV
AU  - Wilcock,E
AU  - Zhang,JE
AU  - Flaherty,L
AU  - Maziere,N
AU  - Cass,E
AU  - Carracedo,AD
AU  - Carlucci,N
AU  - Holmes,A
AU  - Massey,H
AU  - Adeniji,K
AU  - Agranoff,D
AU  - Agwuh,K
AU  - Ail,D
AU  - Alegria,A
AU  - Angus,B
AU  - Ashish,A
AU  - Atkinson,D
AU  - Bari,S
AU  - Barlow,G
AU  - Barnass,S
AU  - Barrett,N
AU  - Bassford,C
AU  - Baxter,D
AU  - Beadsworth,M
DO  - 10.1016/S2213-2600(21)00013-8
EP  - 711
PY  - 2021///
SN  - 2213-2600
SP  - 699
TI  - Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK
T2  - The Lancet Respiratory Medicine
UR  - http://dx.doi.org/10.1016/S2213-2600(21)00013-8
UR  - https://doi.org/10.1016/S2213-2600(21)00013-8
UR  - https://www.sciencedirect.com/science/article/pii/S2213260021000138?via%3Dihub
UR  - http://hdl.handle.net/10044/1/85397
VL  - 9
ER  -
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