Imperial College London
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DrChloeBloom

Faculty of Medicine, National Heart & Lung Institute

Clinical Senior Lecturer in Respiratory Epidemiology
 
 
 
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Contact

 

chloe.bloom06

 
 
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Location

 

Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Conway:2022:10.1164/rccm.202111-2547PP,
author = {Conway, FM and Bloom, CI and Shah, PL},
doi = {10.1164/rccm.202111-2547PP},
journal = {American Journal of Respiratory and Critical Care Medicine},
pages = {696--703},
title = {Susceptibility of patients with airways disease to SARS-CoV-2 infection.},
url = {http://dx.doi.org/10.1164/rccm.202111-2547PP},
volume = {206},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a worldwide pandemic. People with airways disease are at higher risk of respiratory infection, and viruses can trigger respiratory exacerbations. Patients with airways disease may therefore be more susceptible to SARS-CoV-2 infection, development of covid-19, or be at higher risk of adverse outcomes. Here we review susceptibility, based on current epidemiological studies, and explore biological mechanisms. Evidence from multiple large observational studies has shown chronic obstructive pulmonary disease (COPD) is a significant risk factor for covid-19 related mortality. Whether people with asthma are more susceptible to infection or severe outcomes has been much debated but appears to be related to their asthma phenotype and severity. To what extent these differences are biological or influenced by public health non-pharmacological interventions is difficult to quantify. Biological mechanisms that may influence susceptibility and adverse outcomes in airways disease include the increased expression of protein receptors enabling viral cell entry, dysfunctional epithelial airway immunity, type-2 inflammation and the use of inhaled corticosteroids. A better understanding of the susceptibility and mechanisms is essential for developing preventative and therapeutic strategies. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).
AU  - Conway,FM
AU  - Bloom,CI
AU  - Shah,PL
DO  - 10.1164/rccm.202111-2547PP
EP  - 703
PY  - 2022///
SN  - 1073-449X
SP  - 696
TI  - Susceptibility of patients with airways disease to SARS-CoV-2 infection.
T2  - American Journal of Respiratory and Critical Care Medicine
UR  - http://dx.doi.org/10.1164/rccm.202111-2547PP
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35549839
UR  - https://www.atsjournals.org/doi/10.1164/rccm.202111-2547PP
UR  - http://hdl.handle.net/10044/1/96933
VL  - 206
ER  -
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