Imperial College London
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Dr Chris Tomlinson

Faculty of Medicine, Department of Surgery & Cancer

Honorary Research Fellow
 
 
 
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Contact

 

chris.tomlinson

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hoyles:2021:10.1186/s40168-021-01052-7,
author = {Hoyles, L and Mayneris-Perxachs, J and Cardellini, M and Latorre, J and Davato, F and Moreno-Navarette, JM and Arnoriaga-Rodriquez, M and Serino, M and Abbott, J and Barton, RH and Puig, J and Fernandez-Real, X and Ricart, W and Tomlinson, C and Woodbridge, M and Gentileschi, P and Butcher, SA and Holmes, E and Nicholson, JK and Perez-Brocal, V and Moya, A and McClain, D and Burcelin, R and Dumas, M-E and Federici, M and Fernandez-Real, J-M},
doi = {10.1186/s40168-021-01052-7},
journal = {Microbiome},
pages = {1--18},
title = {­Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome},
url = {http://dx.doi.org/10.1186/s40168-021-01052-7},
volume = {9},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: The gut microbiome and iron status are known to play a role in the pathophysiology of non-alcoholic fatty liver disease (NAFLD), although their complex interaction remains unclear.Results: Here, we applied an integrative systems medicine approach (faecal metagenomics, plasma and urine metabolomics, hepatic transcriptomics) in 2 well-characterised human cohorts of subjects with obesity (discovery n = 49 and validation n = 628) and an independent cohort formed by both individuals with and without obesity (n = 130), combined with in vitro and animal models. Serum ferritin levels, as a markers of liver iron stores, were positively associated with liver fat accumulation in parallel with lower gut microbial gene richness, composition and functionality. Specifically, ferritin had strong negative associations with the Pasteurellaceae, Leuconostocaceae and Micrococcaea families. It also had consistent negative associations with several Veillonella, Bifidobacterium and Lactobacillus species, but positive associations with Bacteroides and Prevotella spp. Notably, the ferritin-associated bacterial families had a strong correlation with iron-related liver genes. In addition, several bacterial functions related to iron metabolism (transport, chelation, heme and siderophore biosynthesis) and NAFLD (fatty acid and glutathione biosynthesis) were also associated with the host serum ferritin levels. This iron-related microbiome signature was linked to a transcriptomic and metabolomic signature associated to the degree of liver fat accumulation through hepatic glucose metabolism. In particular, we found a consistent association among serum ferritin, Pasteurellaceae and Micrococcacea families, bacterial functions involved in histidine transport, the host circulating histidine levels and the liver expression of GYS2 and SEC24B. Serum ferritin was also related to bacterial glycine transporters, the host glycine serum levels and the liver expression of glycine transporters. The
AU  - Hoyles,L
AU  - Mayneris-Perxachs,J
AU  - Cardellini,M
AU  - Latorre,J
AU  - Davato,F
AU  - Moreno-Navarette,JM
AU  - Arnoriaga-Rodriquez,M
AU  - Serino,M
AU  - Abbott,J
AU  - Barton,RH
AU  - Puig,J
AU  - Fernandez-Real,X
AU  - Ricart,W
AU  - Tomlinson,C
AU  - Woodbridge,M
AU  - Gentileschi,P
AU  - Butcher,SA
AU  - Holmes,E
AU  - Nicholson,JK
AU  - Perez-Brocal,V
AU  - Moya,A
AU  - McClain,D
AU  - Burcelin,R
AU  - Dumas,M-E
AU  - Federici,M
AU  - Fernandez-Real,J-M
DO  - 10.1186/s40168-021-01052-7
EP  - 18
PY  - 2021///
SN  - 2049-2618
SP  - 1
TI  - ­Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome
T2  - Microbiome
UR  - http://dx.doi.org/10.1186/s40168-021-01052-7
UR  - https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-021-01052-7
UR  - http://hdl.handle.net/10044/1/88724
VL  - 9
ER  -
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