Imperial College London
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DrChristinaAtchison

Faculty of Medicine, School of Public Health

Principal Clinical Academic Fellow
 
 
 
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Contact

 

christina.atchison11

 
 
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Location

 

Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Riley:2021,
author = {Riley, S and Wang, H and Eales, O and Haw, D and Walters, C and Ainslie, K and Atchison, C and Fronterre, C and Diggle, P and Page, A and Prosolek, S and Trotter, AJ and Le, Viet T and Alikhan, N-F and The, COVID-19 Genomics UK Consortium COG-UK and Ashby, D and Donnelly, C and Cooke, G and Barclay, W and Ward, H and Darzi, A and Elliott, P},
title = {REACT-1 round 12 report: resurgence of SARS-CoV-2 infections in England associated with increased frequency of the Delta variant},
url = {http://hdl.handle.net/10044/1/89629},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - BackgroundEngland entered a third national lockdown from 6 January 2021 due to the COVID-19pandemic. Despite a successful vaccine rollout during the first half of 2021, cases andhospitalisations have started to increase since the end of May as the SARS-CoV-2 Delta(B.1.617.2) variant increases in frequency. The final step of relaxation of COVID-19restrictions in England has been delayed from 21 June to 19 July 2021.MethodsThe REal-time Assessment of Community Transmision-1 (REACT-1) study measures theprevalence of swab-positivity among random samples of the population of England. Round12 of REACT-1 obtained self-administered swab collections from participants from 20 May2021 to 7 June 2021; results are compared with those for round 11, in which swabs werecollected from 15 April to 3 May 2021.ResultsBetween rounds 11 and 12, national prevalence increased from 0.10% (0.08%, 0.13%) to0.15% (0.12%, 0.18%). During round 12, we detected exponential growth with a doublingtime of 11 (7.1, 23) days and an R number of 1.44 (1.20, 1.73). The highest prevalence wasfound in the North West at 0.26% (0.16%, 0.41%) compared to 0.05% (0.02%, 0.12%) in theSouth West. In the North West, the locations of positive samples suggested a cluster inGreater Manchester and the east Lancashire area. Prevalence in those aged 5-49 was 2.5times higher at 0.20% (0.16%, 0.26%) compared with those aged 50 years and above at0.08% (0.06%, 0.11%). At the beginning of February 2021, the link between infection ratesand hospitalisations and deaths started to weaken, although in late April 2021, infectionrates and hospital admissions started to reconverge. When split by age, the weakened linkbetween infection rates and hospitalisations at ages 65 years and above was maintained,while the trends converged below the age of 65 years. The majority of the infections in theyounger group occurred in the unvaccinated population or those without a stated vaccinehistory. We observed the rapid replacement of the Alpha (
AU  - Riley,S
AU  - Wang,H
AU  - Eales,O
AU  - Haw,D
AU  - Walters,C
AU  - Ainslie,K
AU  - Atchison,C
AU  - Fronterre,C
AU  - Diggle,P
AU  - Page,A
AU  - Prosolek,S
AU  - Trotter,AJ
AU  - Le,Viet T
AU  - Alikhan,N-F
AU  - The,COVID-19 Genomics UK Consortium COG-UK
AU  - Ashby,D
AU  - Donnelly,C
AU  - Cooke,G
AU  - Barclay,W
AU  - Ward,H
AU  - Darzi,A
AU  - Elliott,P
PY  - 2021///
TI  - REACT-1 round 12 report: resurgence of SARS-CoV-2 infections in England associated with increased frequency of the Delta variant
UR  - http://hdl.handle.net/10044/1/89629
ER  -
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