Imperial College London
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Christophe Stevens

Faculty of Medicine, School of Public Health

Software Engineer/Data Manager
 
 
 
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Contact

 

christophe.stevens Website

 
 
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Location

 

Stadium HouseWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hu:2020:10.1161/CIRCULATIONAHA.119.044795,
author = {Hu, P and Dharmayat, KI and Stevens, CAT and Sharabiani, MTA and Jones, RS and Watts, GF and Genest, J and Ray, KK and Vallejo-Vaz, AJ},
doi = {10.1161/CIRCULATIONAHA.119.044795},
journal = {Circulation},
pages = {1742--1759},
title = {Prevalence of familial hypercholesterolemia among the general population and patients with atherosclerotic cardiovascular disease: a systematic review and meta-analysis.},
url = {http://dx.doi.org/10.1161/CIRCULATIONAHA.119.044795},
volume = {141},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:Contemporary studies suggest that familial hypercholesterolemia (FH) is more frequent than previously reported and increasingly recognized as affecting individuals of all ethnicities and across many regions of the world. Precise estimation of its global prevalence and prevalence across World Health Organization regions is needed to inform policies aiming at early detection and atherosclerotic cardiovascular disease (ASCVD) prevention. The present study aims to provide a comprehensive assessment and more reliable estimation of the prevalence of FH than hitherto possible in the general population (GP) and among patients with ASCVD.Methods:We performed a systematic review and meta-analysis including studies reporting on the prevalence of heterozygous FH in the GP or among those with ASCVD. Studies reporting gene founder effects and focused on homozygous FH were excluded. The search was conducted through Medline, Embase, Cochrane, and Global Health, without time or language restrictions. A random-effects model was applied to estimate the overall pooled prevalence of FH in the general and ASCVD populations separately and by World Health Organization regions.Results:From 3225 articles, 42 studies from the GP and 20 from populations with ASCVD were eligible, reporting on 7 297 363 individuals/24 636 cases of FH and 48 158 patients/2827 cases of FH, respectively. More than 60% of the studies were from Europe. Use of the Dutch Lipid Clinic Network criteria was the commonest diagnostic method. Within the GP, the overall pooled prevalence of FH was 1:311 (95% CI, 1:250–1:397; similar between children [1:364] and adults [1:303], P=0.60; across World Health Organization regions where data were available, P=0.29; and between population-based and electronic health records–based studies, P=0.82). Studies with ≤10 000 participants reported a higher prevalence (1:200–289) compared with larger cohorts (1:365–407; P<0.001). The pooled pre
AU  - Hu,P
AU  - Dharmayat,KI
AU  - Stevens,CAT
AU  - Sharabiani,MTA
AU  - Jones,RS
AU  - Watts,GF
AU  - Genest,J
AU  - Ray,KK
AU  - Vallejo-Vaz,AJ
DO  - 10.1161/CIRCULATIONAHA.119.044795
EP  - 1759
PY  - 2020///
SN  - 0009-7322
SP  - 1742
TI  - Prevalence of familial hypercholesterolemia among the general population and patients with atherosclerotic cardiovascular disease: a systematic review and meta-analysis.
T2  - Circulation
UR  - http://dx.doi.org/10.1161/CIRCULATIONAHA.119.044795
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32468833
UR  - https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.119.044795
UR  - http://hdl.handle.net/10044/1/79503
VL  - 141
ER  -
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