Imperial Centre for Cardiovascular Disease Prevention: EAS FHSC
Christophe is the senior software engineer and Data Manager for the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC), an international initiative aiming to generate large scale robust data on how Familial Hypercholesterolaemia (FH) is detected and managed and the clinical consequences of the current practice on outcomes.
His role consists in programming and testing the data collection webapp as well as the backend data harmonisation/integrations functions. He interacts with national investigators in order to integrate their requirements and suggestions within the application.
Sheffield University: School of Health and Related Research (SCHARR)
As part of his Dissertation for the MSc. in Medical Statistics Christophe was involved in the Sheffield Accelerated Value of Information(SAVI) project and more specifically in developing the Expected Value of Sample Information(EVSI) tool.
This tool allows health economists and scientists involved in cost-effectiveness analysis to compute the EVSI relatively easily. EVSI models the cost of extra information (i.e. a new study) per patient and for a subset of parameters. The EVSI is useful to do research prioritization and to estimate the net benefit of a trial in monetary value.
Continuous Update Project
Christophe was the Database manager of the WCRF Continuous Update project (CUP) at Imperial College London for about 4 years.The CUP merges all the studies concerning Food, Nutrition, Physical Activity, and the Prevention of Cancer in a unique database.
His main duty consisted in coding SQL queries and designing databases in order to answer epidemiologist`s demands. In complement, he programmed the Java 8 application that allows epidemiologists to analyse and manipulate the data.
He integrated R (Rserve) in the java application so that parts of the data analysis process can be done directly in the application ( high vs low forest plot).
A module he developed allowed user generate large datasets(csv, excel) and large reports (rtf, word) directly from the database and via the application.
Christophe implemented a pdf library using mongoDB and solr (search engine) to reference these >13,000 pdfs a java web application (jsf2.2)
In an attempt to speed up the process of literature selection by the epidemiologist, Chrsitophe designed a classification algorithm (using regex-text mining and decision tree CART) that automatically excludes studies from a MedLine file. The output of this algorithm is a RIS file that can be imported in reference manager.