Publications

BibTex format

@article{Shafiei:2023:brain/awac069,
author = {Shafiei, G and Bazinet, V and Dadar, M and Manera, AL and Collins, DL and Dagher, A and Borroni, B and Sanchez-Valle, R and Moreno, F and Laforce, R and Graff, C and Synofzik, M and Galimberti, D and Rowe, JB and Masellis, M and Tartaglia, MC and Finger, E and Vandenberghe, R and de, Mendonça A and Tagliavini, F and Santana, I and Butler, C and Gerhard, A and Danek, A and Levin, J and Otto, M and Sorbi, S and Jiskoot, LC and Seelaar, H and van, Swieten JC and Rohrer, JD and Misic, B and Ducharme, S and Frontotemporal, Lobar Degeneration Neuroimaging Initiative FTLDNI and GENetic, Frontotemporal dementia Initiative GENFI},
doi = {brain/awac069},
journal = {Brain},
pages = {321--336},
title = {Network structure and transcriptomic vulnerability shape atrophy in frontotemporal dementia.},
url = {http://dx.doi.org/10.1093/brain/awac069},
volume = {146},
year = {2023}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Connections among brain regions allow pathological perturbations to spread from a single source region to multiple regions. Patterns of neurodegeneration in multiple diseases, including behavioural variant of frontotemporal dementia (bvFTD), resemble the large-scale functional systems, but how bvFTD-related atrophy patterns relate to structural network organization remains unknown. Here we investigate whether neurodegeneration patterns in sporadic and genetic bvFTD are conditioned by connectome architecture. Regional atrophy patterns were estimated in both genetic bvFTD (75 patients, 247 controls) and sporadic bvFTD (70 patients, 123 controls). First, we identified distributed atrophy patterns in bvFTD, mainly targeting areas associated with the limbic intrinsic network and insular cytoarchitectonic class. Regional atrophy was significantly correlated with atrophy of structurally- and functionally-connected neighbours, demonstrating that network structure shapes atrophy patterns. The anterior insula was identified as the predominant group epicentre of brain atrophy using data-driven and simulation-based methods, with some secondary regions in frontal ventromedial and antero-medial temporal areas. We found that FTD-related genes, namely C9orf72 and TARDBP, confer local transcriptomic vulnerability to the disease, modulating the propagation of pathology through the connectome. Collectively, our results demonstrate that atrophy patterns in sporadic and genetic bvFTD are jointly shaped by global connectome architecture and local transcriptomic vulnerability, providing an explanation as to how heterogenous pathological entities can lead to the same clinical syndrome.
AU  - Shafiei,G
AU  - Bazinet,V
AU  - Dadar,M
AU  - Manera,AL
AU  - Collins,DL
AU  - Dagher,A
AU  - Borroni,B
AU  - Sanchez-Valle,R
AU  - Moreno,F
AU  - Laforce,R
AU  - Graff,C
AU  - Synofzik,M
AU  - Galimberti,D
AU  - Rowe,JB
AU  - Masellis,M
AU  - Tartaglia,MC
AU  - Finger,E
AU  - Vandenberghe,R
AU  - de,Mendonça A
AU  - Tagliavini,F
AU  - Santana,I
AU  - Butler,C
AU  - Gerhard,A
AU  - Danek,A
AU  - Levin,J
AU  - Otto,M
AU  - Sorbi,S
AU  - Jiskoot,LC
AU  - Seelaar,H
AU  - van,Swieten JC
AU  - Rohrer,JD
AU  - Misic,B
AU  - Ducharme,S
AU  - Frontotemporal,Lobar Degeneration Neuroimaging Initiative FTLDNI
AU  - GENetic,Frontotemporal dementia Initiative GENFI
DO  - brain/awac069
EP  - 336
PY  - 2023///
SP  - 321
TI  - Network structure and transcriptomic vulnerability shape atrophy in frontotemporal dementia.
T2  - Brain
UR  - http://dx.doi.org/10.1093/brain/awac069
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35188955
VL  - 146
ER  -

Download

DrChristopherButler

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)