Imperial College London
Portrait Picture

Professor Chris Dunsby

Faculty of Natural Sciences, Department of Physics

Professor of Biomedical Optics
 
 
 
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Contact

 

+44 (0)20 7594 7755christopher.dunsby Website

 
 
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Location

 

622Blackett LaboratorySouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zhang:2018:10.1063/1.5029874,
author = {Zhang, G and Harput, S and Lin, S and Christensen-Jeffries, K and Leow, CH and Brown, J and Dunsby, C and Eckersley, R and Tang, M},
doi = {10.1063/1.5029874},
journal = {Applied Physics Letters},
pages = {014101--1--014101--5},
title = {Acoustic wave sparsely activated localization microscopy (AWSALM): super-resolution ultrasound imaging using acoustic activation and deactivation of nanodroplets},
url = {http://dx.doi.org/10.1063/1.5029874},
volume = {113},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Photo-activated localization microscopy (PALM) has revolutionized the field of fluorescence microscopy by breaking the diffraction limit in spatial resolution. In this study, “acoustic wave sparsely activated localization microscopy (AWSALM),” an acoustic counterpart of PALM, is developed to super-resolve structures which cannot be resolved by conventional B-mode imaging. AWSALM utilizes acoustic waves to sparsely and stochastically activate decafluorobutane nanodroplets by acoustic vaporization and to simultaneously deactivate the existing vaporized nanodroplets via acoustic destruction. In this method, activation, imaging, and deactivation are all performed using acoustic waves. Experimental results show that sub-wavelength micro-structures not resolvable by standard B-mode ultrasound images can be separated by AWSALM. This technique is flow independent and does not require a low concentration of contrast agents, as is required by current ultrasound super resolution techniques. Acoustic activation and deactivation can be controlled by adjusting the acoustic pressure, which remains well within the FDA approved safety range. In conclusion, this study shows the promise of a flow and contrast agent concentration independent super-resolution ultrasound technique which has potential to be faster and go beyond vascular imaging.
AU  - Zhang,G
AU  - Harput,S
AU  - Lin,S
AU  - Christensen-Jeffries,K
AU  - Leow,CH
AU  - Brown,J
AU  - Dunsby,C
AU  - Eckersley,R
AU  - Tang,M
DO  - 10.1063/1.5029874
EP  - 1
PY  - 2018///
SN  - 0003-6951
SP  - 014101
TI  - Acoustic wave sparsely activated localization microscopy (AWSALM): super-resolution ultrasound imaging using acoustic activation and deactivation of nanodroplets
T2  - Applied Physics Letters
UR  - http://dx.doi.org/10.1063/1.5029874
UR  - https://aip.scitation.org/doi/10.1063/1.5029874
UR  - http://hdl.handle.net/10044/1/59994
VL  - 113
ER  -
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