Imperial College London
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Professor Chris Gale

Faculty of Medicine, School of Public Health

Professor of Neonatal Medicine
 
 
 
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Contact

 

+44 (0)20 3315 3519christopher.gale Website

 
 
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Location

 

Academic Neonatal Medicine, H4.4,Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Knight:2020:10.1136/bmj.m2107,
author = {Knight, M and Bunch, K and Vousden, N and Morris, E and Simpson, N and Gale, C and O'Brien, P and Quigley, M and Brocklehurst, P and Kurinczuk, JJ and UK, Obstetric Surveillance System SARS-CoV-2 Infection in Pregnancy Collaborative Group},
doi = {10.1136/bmj.m2107},
journal = {BMJ},
pages = {1--7},
title = {Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study.},
url = {http://dx.doi.org/10.1136/bmj.m2107},
volume = {369},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVES: To describe a national cohort of pregnant women admitted to hospital with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the UK, identify factors associated with infection, and describe outcomes, including transmission of infection, for mothers and infants. DESIGN: Prospective national population based cohort study using the UK Obstetric Surveillance System (UKOSS). SETTING: All 194 obstetric units in the UK. PARTICIPANTS: 427 pregnant women admitted to hospital with confirmed SARS-CoV-2 infection between 1 March 2020 and 14 April 2020. MAIN OUTCOME MEASURES: Incidence of maternal hospital admission and infant infection. Rates of maternal death, level 3 critical care unit admission, fetal loss, caesarean birth, preterm birth, stillbirth, early neonatal death, and neonatal unit admission. RESULTS: The estimated incidence of admission to hospital with confirmed SARS-CoV-2 infection in pregnancy was 4.9 (95% confidence interval 4.5 to 5.4) per 1000 maternities. 233 (56%) pregnant women admitted to hospital with SARS-CoV-2 infection in pregnancy were from black or other ethnic minority groups, 281 (69%) were overweight or obese, 175 (41%) were aged 35 or over, and 145 (34%) had pre-existing comorbidities. 266 (62%) women gave birth or had a pregnancy loss; 196 (73%) gave birth at term. Forty one (10%) women admitted to hospital needed respiratory support, and five (1%) women died. Twelve (5%) of 265 infants tested positive for SARS-CoV-2 RNA, six of them within the first 12 hours after birth. CONCLUSIONS: Most pregnant women admitted to hospital with SARS-CoV-2 infection were in the late second or third trimester, supporting guidance for continued social distancing measures in later pregnancy. Most had good outcomes, and transmission of SARS-CoV-2 to infants was uncommon. The high proportion of women from black or minority ethnic groups admitted with infection needs urgent investigation and explanation. STUDY REGISTRATION: ISRCTN 4
AU  - Knight,M
AU  - Bunch,K
AU  - Vousden,N
AU  - Morris,E
AU  - Simpson,N
AU  - Gale,C
AU  - O'Brien,P
AU  - Quigley,M
AU  - Brocklehurst,P
AU  - Kurinczuk,JJ
AU  - UK,Obstetric Surveillance System SARS-CoV-2 Infection in Pregnancy Collaborative Group
DO  - 10.1136/bmj.m2107
EP  - 7
PY  - 2020///
SN  - 1759-2151
SP  - 1
TI  - Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study.
T2  - BMJ
UR  - http://dx.doi.org/10.1136/bmj.m2107
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32513659
UR  - https://www.bmj.com/content/369/bmj.m2107
UR  - http://hdl.handle.net/10044/1/79956
VL  - 369
ER  -
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