Imperial College London
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MrChristopherPeters

Faculty of Medicine, Department of Surgery & Cancer

Clinical Senior Lecturer in Upper GI
 
 
 
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christopher.peters CV

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Frankell:2019:10.1038/s41588-018-0331-5,
author = {Frankell, AM and Jammula, S and Li, X and Contino, G and Killcoyne, S and Abbas, S and Perner, J and Bower, L and Devonshire, G and Cocks, E and Grehan, N and Mok, J and O'Donovan, M and MacRae, S and Eldridge, MD and Tavare, S and Fitzgerald, RC and Noorani, A and Edwards, PAW and Grehanl, N and Nutzinger, B and Hughes, CI and Fidziukiewicz, E and Northrop, A and de, la Rue R and Katz-Summercorn, A and Loureda, D and Miremadi, A and Malhotra, S and Tripathi, M and Lynch, AG and Eldridge, M and Secrier, M and Davies, J and Crichton, C and Carro, N and Safranek, P and Hindmarsh, A and Sujendran, V and Hayes, SJ and Ang, Y and Sharrocks, A and Preston, SR and Oakes, S and Bagwan, I and Save, V and Skipworth, RJE and Hupp, TR and ONeill, JR and Tucker, O and Beggs, A and Taniere, P and Puig, S and Underwood, T and Walker, RC and Grace, BL and Barr, H and Shepherd, N and Old, O and Lagergren, J and Gossage, J and Davies, A and Chang, F and Zylstra, J and Mahadeva, U and Goh, V and Ciccarel},
doi = {10.1038/s41588-018-0331-5},
journal = {Nature Genetics},
pages = {506--516},
title = {The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic},
url = {http://dx.doi.org/10.1038/s41588-018-0331-5},
volume = {51},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Esophageal adenocarcinoma (EAC) is a poor-prognosis cancer type with rapidly rising incidence. Understanding of the genetic events driving EAC development is limited, and there are few molecular biomarkers for prognostication or therapeutics. Using a cohort of 551 genomically characterized EACs with matched RNA sequencing data, we discovered 77 EAC driver genes and 21 noncoding driver elements. We identified a mean of 4.4 driver events per tumor, which were derived more commonly from mutations than copy number alterations, and compared the prevelence of these mutations to the exome-wide mutational excess calculated using non-synonymous to synonymous mutation ratios (dN/dS). We observed mutual exclusivity or co-occurrence of events within and between several dysregulated EAC pathways, a result suggestive of strong functional relationships. Indicators of poor prognosis (SMAD4 and GATA4) were verified in independent cohorts with significant predictive value. Over 50% of EACs contained sensitizing events for CDK4 and CDK6 inhibitors, which were highly correlated with clinically relevant sensitivity in a panel of EAC cell lines and organoids.
AU  - Frankell,AM
AU  - Jammula,S
AU  - Li,X
AU  - Contino,G
AU  - Killcoyne,S
AU  - Abbas,S
AU  - Perner,J
AU  - Bower,L
AU  - Devonshire,G
AU  - Cocks,E
AU  - Grehan,N
AU  - Mok,J
AU  - O'Donovan,M
AU  - MacRae,S
AU  - Eldridge,MD
AU  - Tavare,S
AU  - Fitzgerald,RC
AU  - Noorani,A
AU  - Edwards,PAW
AU  - Grehanl,N
AU  - Nutzinger,B
AU  - Hughes,CI
AU  - Fidziukiewicz,E
AU  - Northrop,A
AU  - de,la Rue R
AU  - Katz-Summercorn,A
AU  - Loureda,D
AU  - Miremadi,A
AU  - Malhotra,S
AU  - Tripathi,M
AU  - Lynch,AG
AU  - Eldridge,M
AU  - Secrier,M
AU  - Davies,J
AU  - Crichton,C
AU  - Carro,N
AU  - Safranek,P
AU  - Hindmarsh,A
AU  - Sujendran,V
AU  - Hayes,SJ
AU  - Ang,Y
AU  - Sharrocks,A
AU  - Preston,SR
AU  - Oakes,S
AU  - Bagwan,I
AU  - Save,V
AU  - Skipworth,RJE
AU  - Hupp,TR
AU  - ONeill,JR
AU  - Tucker,O
AU  - Beggs,A
AU  - Taniere,P
AU  - Puig,S
AU  - Underwood,T
AU  - Walker,RC
AU  - Grace,BL
AU  - Barr,H
AU  - Shepherd,N
AU  - Old,O
AU  - Lagergren,J
AU  - Gossage,J
AU  - Davies,A
AU  - Chang,F
AU  - Zylstra,J
AU  - Mahadeva,U
AU  - Goh,V
AU  - Ciccarelli,FD
AU  - Sanders,G
AU  - Berrisford,R
AU  - Harden,C
AU  - Lewis,M
AU  - Cheong,E
AU  - Kumar,B
AU  - Parsons,SL
AU  - Soomro,I
AU  - Kaye,P
AU  - Saunders,J
AU  - Lovat,L
AU  - Haidry,R
AU  - Igali,L
AU  - Scott,M
AU  - Sothi,S
AU  - Suortamo,S
AU  - Lishman,S
AU  - Hanna,GB
AU  - Moorthy,K
AU  - Peters,CJ
AU  - Grabowska,A
AU  - Turkington,R
AU  - McManus,D
AU  - Coleman,H
AU  - Khoo,D
AU  - Fickling,W
DO  - 10.1038/s41588-018-0331-5
EP  - 516
PY  - 2019///
SN  - 1061-4036
SP  - 506
TI  - The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic
T2  - Nature Genetics
UR  - http://dx.doi.org/10.1038/s41588-018-0331-5
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000459947200018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/69489
VL  - 51
ER  -
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