Imperial College London
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MrChristopherPeters

Faculty of Medicine, Department of Surgery & Cancer

Clinical Senior Lecturer in Upper GI
 
 
 
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Contact

 

christopher.peters CV

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Nazarian:2021:bjs/znab361.142,
author = {Nazarian, S and Gkouzionis, I and Anandakumar, A and Patel, N and Elson, D and Peters, C},
doi = {bjs/znab361.142},
pages = {41--41},
publisher = {British Journal of Surgery Society},
title = {Using diffuse reflectance spectroscopy (DRS) to identify tumour and non-tumour tissue in upper gastrointestinal specimens},
url = {http://dx.doi.org/10.1093/bjs/znab361.142},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - AimCancers of the upper gastrointestinal (GI) tract remain a major contributor to the global cancer risk. Surgery aims to completely resect tumour with clear margins, whilst preserving as much surrounding tissue. Diffuse reflectance spectroscopy (DRS) is a novel technique that presents a promising advancement in cancer diagnosis. We have developed a novel DRS system with tracking capability. Our aim is to classify tumour and non-tumour GI tissue in real-time using this device to aid intra-operative analysis of resection margins.MethodAn ex-vivo study was undertaken in which data was collected from consecutive patients undergoing upper GI cancer resection surgery between August 2020- January 2021. A hand-held DRS probe and tracking system was used on normal and cancerous tissue to obtain spectral information. After acquisition of all spectra, a classification system using histopathology results was created. A user interface was developed using Python 3.6 and Qt5. A support vector machine was used to classify the results.ResultsThe data included 4974 normal spectra and 2108 tumour spectra. The overall accuracy of the DRS probe in differentiating normal versus tumour tissue was 88.08% for the stomach (sensitivity 84.8%, specificity 89.3%), and 91.42% for the oesophagus (sensitivity 76.3%, specificity 98.9%).ConclusionWe have developed a successful DRS system with tracking capability, able to process thousands of spectra in a small timeframe, which can be used in real-time to distinguish tumour and non-tumour tissue. This can be used for intra-operative decision-making during upper GI cancer surgery to help select the best resection plane.
AU  - Nazarian,S
AU  - Gkouzionis,I
AU  - Anandakumar,A
AU  - Patel,N
AU  - Elson,D
AU  - Peters,C
DO  - bjs/znab361.142
EP  - 41
PB  - British Journal of Surgery Society
PY  - 2021///
SN  - 0007-1323
SP  - 41
TI  - Using diffuse reflectance spectroscopy (DRS) to identify tumour and non-tumour tissue in upper gastrointestinal specimens
UR  - http://dx.doi.org/10.1093/bjs/znab361.142
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000714625800645&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://academic.oup.com/bjs/article/108/Supplement_7/znab361.142/6411257
UR  - http://hdl.handle.net/10044/1/94010
ER  -
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