Publications
140 results found
Rao C, Ali NA, Yacoub MH, et al., 2011, The Use of Induced Pluripotent Stem Cell Derived Cardiomyocytes as a Model of Human Disease, Aswan Heart Science Centre: Science and Practice Series
Rao C, Wong KA, Athanasiou T, 2011, An Introduction to Cost-Effectiveness Analysis, Evidence Synthesis in Healthcare: A Practical Handbook for Clinicians, Editors: Darzi, Athanasiou, Berlin Heidelberg, Publisher: Springer-Verlag, ISBN: 978-0-85729-175-2
Rao C, Darzi A, Athanasiou T, 2011, Practical Examples of the Application of Decision Analysis in Healthcare, Evidence Synthesis in Healthcare: A Practical Handbook for Clinicians, Editors: Darzi, Athanasiou, Berlin Heidelberg, Publisher: Springer-Verlag, ISBN: 978-0-85729-175-2
Rao C, Darzi A, Athanasiou T, 2011, An Introduction to Decision Analysis, Evidence Synthesis in Healthcare: A Practical Handbook for Clinicians, Editors: Darzi, Athanasiou, Berlin Heidelberg, Publisher: Springer-Verlag, ISBN: 978-0-85729-175-2
Rao C, Jiwan S, Athanasiou T, 2011, A Practical Example of Cost-Effectiveness Analysis, Evidence Synthesis in Healthcare: A Practical Handbook for Clinicians, Editors: Darzi, Athanasiou, Berlin Heidelberg, Publisher: Springer-Verlag, ISBN: 978-0-85729-175-2
Rao C, Chaudhry U, Al-Saud SA, et al., 2011, Structured Culture Scaffolds force the Maturation of Calcium Transients in Rat Neonatal Ventricular Myocytes, Proceedings of The Physiological Society, Physiology 2011, ISSN: 1749-6187
Rao C, Ali NA, Athanasiou T, et al., 2011, Phenotype and Developmental Potential of Cardiomyocytes from Induced Pluripotent Stem Cells and Human Embryonic Stem Cells, Nuclear Reprogramming and Stem Cells, Editors: Ainscough, Yamanaka, Tada, Berlin Heidelberg, Publisher: Humana Press, ISBN: 978-1-61779-224-3
Research into the field of stem cell biology has developed exponentially over recent years, and is beginning to offer significant promise for unravelling the molecular basis of a multitude of disease states. Importantly, in addition to offering the opportunity to delve deeply into the mechanisms that drive disease aetiology the research is realistically opening the doors for development of targeted and personalized therapeutic applications that many considered, until recently, to be nothing more that a far fetched dream. This volume provides a timely glimpse into the methods that have been developed to instigate, and the mechanisms that have been identified to drive, the process of nuclear reprogramming, chronicling how the field has developed over the last 50-60 years. Since the early 1950s a small number of notable experiments have provided significant impetus to the field, primarily the demonstration of reprogramming ability, first by the complex cytoplasmic milieu that constitutes the amphibian egg, then that of the mammalian egg, and finally that of the mammalian embryonic stem cell. Most recently, the demonstration that a limited pool of defined molecules is capable of reprogramming a multitude of cell types has provided massive impetus and facilitated transition towards realistic therapeutic application. We have therefore reproduced some of the key articles that elegantly document these dramatic stages of development of the field in an inclusive appendix to the book, for the benefit of readers keen to investigate the history of how the field of stem cell biology has evolved. Owing to the ever broadening nature of this field, and the incredible rate at which it is evolving, the main content of this volume focuses on areas that have shown significant movement in recent years, are most likely to translate into personalized therapeutic application, and thus provide greatest potential for significant impact on human health in the not too distant future. We recogni
Ibrahim M, Miocic-Lazarevic S, Siedlecka U, et al., 2011, Telethonin regulates transverse (t)-tubule structure and Ca2+ induced Ca2+ release (CICR) in mouse ventricular myocytes, Proceedings of The Physiological Society, Physiology 2011, ISSN: 1749-6187
Ibrahim M, Navaratnarajah M, Siedlecka U, et al., 2010, Mechanical Unloading Of Failing Hearts Normalises Ca2+-induced Ca2+ Release By Reverse Remodelling Of The T-tubule System, Aswan Heart Science Centre: Science and Practice Series
Vecht JA, Saso S, Rao C, et al., 2010, Atrial septal defect closure is associated with a reduced prevalence of atrial tachyarrhythmia in the short to medium term: a systematic review and meta-analysis, HEART, Vol: 96, Pages: 1789-1797, ISSN: 1355-6037
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- Citations: 53
Patel VM, Warren O, Humphris P, et al., 2010, What does leadership in surgery entail?, ANZ J Surg
Rao C, Patel V, Ibrahim M, et al., 2010, Leadership in cardiac surgery, Eur J Cardiothorac Surg
Athanasiou T, Rao C, Buxton BF, 2010, META-ANALYSIS COVERS THE HORIZON WHEN THE LITERATURE SEARCH IS UNDERTAKEN THROUGH A KEYHOLE, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 139, Pages: 1669-1670, ISSN: 0022-5223
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- Citations: 3
Vecht JA, von Segesser LK, Ashrafian H, et al., 2010, Translation to success of surgical innovation, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 37, Pages: 613-625, ISSN: 1010-7940
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- Citations: 12
Saso S, James D, Vecht JA, et al., 2010, Effect of Skeletonization of the Internal Thoracic Artery for Coronary Revascularization on the Incidence of Sternal Wound Infection, ANNALS OF THORACIC SURGERY, Vol: 89, Pages: 661-670, ISSN: 0003-4975
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- Citations: 61
Saso S, Vecht JA, Rao C, et al., 2010, Statin therapy may influence the incidence of postoperative atrial fibrillation: what is the evidence?, Texas Heart Institute Journal, Vol: 36, Pages: 521-529, ISSN: 1526-6702
Atrial fibrillation is the most common postoperative arrhythmia in patients who undergo cardiac surgery. We sought to determine whether the administration of statins reduces the incidence of postoperative atrial fibrillation in cardiac surgery patients. We performed a meta-analysis on all studies published between 2004 and 2008 that reported comparisons between statin treatment or nontreatment in these patients. Our primary focus was the incidence of postoperative atrial fibrillation. Random-effects modeling and sensitivity analysis were used to evaluate the consistency of the calculated treatment effect. Ten qualifying studies generated a total of 4,459 patients. The incidence of postoperative atrial fibrillation was 22.6% (622/2,758) in the statin-treated group and 29.8% (507/1,701) in the untreated group. Using the random-effects model, we calculated an odds ratio (OR) of 0.60 (95% confidence interval [CI], 0.48-0.76). When we considered only the 4 randomized studies (919 patients) in order to reduce the effects of heterogeneity, this significant reduction in the incidence of postoperative atrial fibrillation in the statin group was maintained (OR, 0.55; 95% CI, 0.41-0.73) with no heterogeneity (chi2 of heterogeneity, 2.96; P = 0.4). In studies wherein only coronary artery bypass grafting was performed, statin treatment decreased postoperative atrial fibrillation (OR, 0.64; 95% CI, 0.43-0.95). We conclude that statin administration results in a reduction in the incidence of atrial fibrillation in patients who undergo cardiac surgery. Further research into the underlying mechanism can elucidate possible relationships between the dosage and type of statin used.
Hanna ARG, Rao C, Athanasiou T, 2010, Graphs in Statistical Analysis, Key Topics in Surgical Research and Methodology, Editors: Athanasiou, Debas, Darzi, Berlin Heidelberg, Publisher: Springer-Verlag, Pages: 441-476, ISBN: 978-3-540-71914-4
Rao C, Athanasiou T, 2010, How to Write a Book Proposal, Key Topics in Surgical Research and Methodology, Editors: Athanasiou, Debas, Darzi, Berlin Heidelberg, Publisher: Springer-Verlag, Pages: 611-614, ISBN: 978-3-540-71914-4
Roberts A, 2010, Anatomy Researcher and Advisor: The Complete Human Body, London, Publisher: Dorling Kindersley, ISBN: 9781405347495
The Complete Human Body covers the development, form, function and disorders of thehuman body, all brought to life by incredible state-of-the-art 3D computer ...
Rao C, Athanasiou T, 2010, Value of Information Analysis, Key Topics in Surgical Research and Methodology, Editors: Athanasiou, Debas, Darzi, Berlin Heidelberg, Publisher: Springer-Verlag, Pages: 421-428, ISBN: 978-3-540-71914-4
Rao C, Athanasiou T, 2010, Decision Analysis, Key Topics in Surgical Research and Methodology, Editors: Athanasiou, Debas, Darzi, Berlin Heidelberg, Publisher: Springer-Verlag, Pages: 399-410, ISBN: 978-3-540-71914-4
Rao C, Athanasiou T, 2010, Cost-Effectiveness Analysis, Key Topics in Surgical Research and Methodology, Editors: Athanasiou, Debas, Darzi, Berlin Heidelberg, Publisher: Springer-Verlag, Pages: 411-420, ISBN: 978-3-540-71914-4
Ashrafian H, Rao C, Athanasiou T, 2009, Too much benchmarking Reply, LANCET, Vol: 374, Pages: 1963-1963, ISSN: 0140-6736
Kidher ES, Perera R, Rao C, et al., 2009, A rare case of suture material obstructing the closure mechanism of a prosthetic aortic valve: a case report, Cases Journal, Vol: 2, ISSN: 1757-1626
Prosthetic aortic valve dysfunction presenting as aortic regurgitation is a complication of mechanical valve replacement. We describe a case of late valve dysfunction caused by an annular suture of excessive length obstructing the closure mechanism of a bileaflet prosthetic valve.We present this rare cause of valve dysfunction in an 80-year-old male patient who presented with haemolysis and dyspnoea. At the time of operation it was found that a long vertically positioned annular valve suture was interfering with the normal closure mechanism of one of the prosthetic leaflets causing eccentric regurgitation jets. These findings were misdiagnosed as paravalvular leaks on the preoperative transoesophageal echo. No paravalvular leak was identified intraoperatively. After removal of the responsible suture normal prosthetic valve function was restored.Whilst early aortic valve dysfunction caused by suture material has previously been reported, this is the first report of suture material causing late dysfunction.
Saso S, Vecht JA, Rao C, et al., 2009, Statin Therapy May Influence the Incidence of Postoperative Atrial Fibrillation What Is the Evidence?, TEXAS HEART INSTITUTE JOURNAL, Vol: 36, Pages: 521-529, ISSN: 0730-2347
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- Citations: 10
Aziz O, Skapinakis P, Rahman S, et al., 2009, Behavioural interventions for smoking cessation in patients hospitalised for a major cardiovascular event, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 137, Pages: 171-174, ISSN: 0167-5273
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- Citations: 9
Panesar SS, Rao C, Vecht JA, et al., 2009, Development of the Veritas plot and its application in cardiac surgery: an evidence-synthesis graphic tool for the clinician to assess multiple meta-analyses reporting on a common outcome, CANADIAN JOURNAL OF SURGERY, Vol: 52, Pages: E137-E145, ISSN: 0008-428X
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- Citations: 7
Ashrafian H, Rao C, Darzi A, et al., 2009, Benchmarking in surgical research, LANCET, Vol: 374, Pages: 1045-1047, ISSN: 0140-6736
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- Citations: 13
Ashrafian H, Bueter M, Ahmed K, et al., 2009, Food preference after Roux-en-Y gastric bypass surgery, 95th Annual Clinical Congress of the American-College-of-Surgeons/64th Annual Sessions of the Owen H Wangensteen Forum on Fundamental Surgical Problems, Publisher: ELSEVIER SCIENCE INC, Pages: S14-S14, ISSN: 1072-7515
Mayer EK, Bottle A, Rao C, et al., 2009, Funnel Plots and Their Emerging Application in Surgery, ANNALS OF SURGERY, Vol: 249, Pages: 376-383, ISSN: 0003-4932
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- Citations: 43
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