Imperial College London
Alternate

Chris Rao

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Research Fellow
 
 
 
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Summary

 

Publications

Citation

BibTex format

@article{Hunt:2022:10.1136/bmjopen-2021-059940,
author = {Hunt, N and Rao, C and Logan, R and Chandrabalan, V and Oakey, J and Ainsworth, C and Smith, N and Banerjee, S and Myers, M},
doi = {10.1136/bmjopen-2021-059940},
journal = {BMJ Open},
pages = {1--7},
title = {A cohort study of duplicate faecal immunochemical testing in patients at risk of colorectal cancer from North-West England},
url = {http://dx.doi.org/10.1136/bmjopen-2021-059940},
volume = {12},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives We sought to investigate if duplicate faecal immunochemical testing (FIT) sampling improves the negative and positive predictive value of patients thought to be at risk of colorectal cancer (CRC). Specifically, we aimed to investigate whether the proportion of FIT-negative CRC missed by a single FIT test in symptomatic patients could be reduced by duplicate FIT testing.Design A retrospective service evaluation cohort study of the diagnostic accuracy of duplicate FIT testing.Setting Patients referred from primary care with suspected CRC to four secondary care trusts in North-West England.Participants 28 622 patients over 18-years-old with lower gastrointestinal symptoms suggestive of CRC who completed two FIT samples.Primary and secondary outcome measures The performance of duplicate FIT for detecting CRC at a threshold of 10 µgHb/g.Results The sensitivity if either test was >10 µgHb/g was 0.978 (0.955–0.989), specificity was 0.662 (0.657–0.668), positive predictive value 0.031 (0.028–0.035) and negative predictive value 1.00 (0.999–1.00). Despite two-thirds of patients (18952) being negative following two tests, at this threshold only seven CRC were missed over a 26-month period. All seven patients had other high-risk features which should have prompted investigation.Conclusions This study suggests that in routine NHS practice, a duplicate FIT sample strategy together with clinical evaluation for evidence of anaemia and weight loss is superior to a single FIT sample alone and would allow sym
AU  - Hunt,N
AU  - Rao,C
AU  - Logan,R
AU  - Chandrabalan,V
AU  - Oakey,J
AU  - Ainsworth,C
AU  - Smith,N
AU  - Banerjee,S
AU  - Myers,M
DO  - 10.1136/bmjopen-2021-059940
EP  - 7
PY  - 2022///
SN  - 2044-6055
SP  - 1
TI  - A cohort study of duplicate faecal immunochemical testing in patients at risk of colorectal cancer from North-West England
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2021-059940
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000783232500025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://bmjopen.bmj.com/content/12/4/e059940
UR  - http://hdl.handle.net/10044/1/100391
VL  - 12
ER  -
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