Imperial College London
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DrChunghoLau

Faculty of Medicine, School of Public Health

Research Associate
 
 
 
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Contact

 

chungho.lau Website

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Maitre:2021:10.1101/2021.05.04.21256605,
author = {Maitre, L and Bustamante, M and Hernández-Ferrer, C and Thiel, D and Lau, C-H and Siskos, A and Vives-Usano, M and Ruiz-Arenas, C and Robinson, O and Mason, D and Wright, J and Cadiou, S and Slama, R and Heude, B and Gallego-Paüls, M and Casas, M and Sunyer, J and Papadopoulou, EZ and Gutzkow, KB and Andrusaityte, S and Grazuleviciene, R and Vafeiadi, M and Chatzi, L and Sakhi, AK and Thomsen, C and Tamayo, I and Nieuwenhuijsen, M and Urquiza, J and Borràs, E and Sabidó, E and Quintela, I and Carracedo, Á and Estivill, X and Coen, M and González, JR and Keun, HC and Vrijheid, M},
doi = {10.1101/2021.05.04.21256605},
title = {Multi-omics signatures of the human early life exposome},
url = {http://dx.doi.org/10.1101/2021.05.04.21256605},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - <jats:title>Summary</jats:title><jats:p>Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1,301 mother-child pairs, we associated individual exposomes consisting of >100 chemical, physical and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, metabolome and proteins) in childhood. We identified 1,170 associations, 249 in pregnancy and 921 in childhood, which revealed potential biological responses and sources of exposure. The methylome best captures the persistent influence of pregnancy exposures, including maternal smoking; while childhood exposures were associated with features from all omics layers, revealing novel signatures for indoor air quality, essential trace elements, endocrine disruptors and weather conditions. This study provides a unique resource (<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://helixomics.isglobal.org/">https://helixomics.isglobal.org/</jats:ext-link>) to guide future investigation on the biological effects of the early life exposome.</jats:p>
AU  - Maitre,L
AU  - Bustamante,M
AU  - Hernández-Ferrer,C
AU  - Thiel,D
AU  - Lau,C-H
AU  - Siskos,A
AU  - Vives-Usano,M
AU  - Ruiz-Arenas,C
AU  - Robinson,O
AU  - Mason,D
AU  - Wright,J
AU  - Cadiou,S
AU  - Slama,R
AU  - Heude,B
AU  - Gallego-Paüls,M
AU  - Casas,M
AU  - Sunyer,J
AU  - Papadopoulou,EZ
AU  - Gutzkow,KB
AU  - Andrusaityte,S
AU  - Grazuleviciene,R
AU  - Vafeiadi,M
AU  - Chatzi,L
AU  - Sakhi,AK
AU  - Thomsen,C
AU  - Tamayo,I
AU  - Nieuwenhuijsen,M
AU  - Urquiza,J
AU  - Borràs,E
AU  - Sabidó,E
AU  - Quintela,I
AU  - Carracedo,Á
AU  - Estivill,X
AU  - Coen,M
AU  - González,JR
AU  - Keun,HC
AU  - Vrijheid,M
DO  - 10.1101/2021.05.04.21256605
PY  - 2021///
TI  - Multi-omics signatures of the human early life exposome
UR  - http://dx.doi.org/10.1101/2021.05.04.21256605
ER  -
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