Imperial College London
Alternate

DrClaireFletcher

Faculty of Medicine, Department of Surgery & Cancer

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 2821claire.fletcher07 CV

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Eringyte:2020:10.1016/j.ajur.2020.06.003,
author = {Eringyte, I and Zamarbide, Losada JN and Powell, SM and Bevan, CL and Fletcher, CE},
doi = {10.1016/j.ajur.2020.06.003},
journal = {Asian Journal of Urology},
pages = {233--250},
title = {Coordinated AR and microRNA regulation in prostate cancer},
url = {http://dx.doi.org/10.1016/j.ajur.2020.06.003},
volume = {7},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The androgen receptor (AR) remains a key driver of prostate cancer (PCa) progression, even in the advanced castrate-resistant stage, where testicular androgens are absent. It is therefore of critical importance to understand the molecular mechanisms governing its activity and regulation during prostate tumourigenesis. MicroRNAs (miRs) are small ∼22 nt non-coding RNAs that regulate target gene, often through association with 3' untranslated regions (3'UTRs) of transcripts. They display dysregulation during cancer progression, can function as oncogenes or tumour suppressors, and are increasingly recognised as targets or regulators of hormonal action. Thus, understanding factors which modulate miRs synthesis is essential. There is increasing evidence for complex and dynamic bi-directional cross-talk between the multi-step miR biogenesis cascade and the AR signalling axis in PCa. This review summarises the wealth of mechanisms by which miRs are regulated by AR, and conversely, how miRs impact AR's transcriptional activity, including that of AR splice variants. In addition, we assess the implications of the convergence of these pathways on the clinical employment of miRs as PCa biomarkers and therapeutic targets.
AU  - Eringyte,I
AU  - Zamarbide,Losada JN
AU  - Powell,SM
AU  - Bevan,CL
AU  - Fletcher,CE
DO  - 10.1016/j.ajur.2020.06.003
EP  - 250
PY  - 2020///
SN  - 2214-3882
SP  - 233
TI  - Coordinated AR and microRNA regulation in prostate cancer
T2  - Asian Journal of Urology
UR  - http://dx.doi.org/10.1016/j.ajur.2020.06.003
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32742925
UR  - http://hdl.handle.net/10044/1/81564
VL  - 7
ER  -
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