Imperial College London
Alternate

DrClaireFletcher

Faculty of Medicine, Department of Surgery & Cancer

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 2821claire.fletcher07 CV

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fletcher:2017:nar/gkw938,
author = {Fletcher, CE and Godfrey, JD and Shibakawa, A and Bushell, M and Bevan, CL},
doi = {nar/gkw938},
journal = {Nucleic Acid Research},
pages = {2809--2828},
title = {A novel role for GSK3β as a modulator of Drosha microprocessor activity and MicroRNA biogenesis},
url = {http://dx.doi.org/10.1093/nar/gkw938},
volume = {45},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Regulation of microRNA (miR) biogenesis is complex and stringently controlled. Here, we identify the kinase GSK3ß as a important modulator of miR biogenesis at Microprocessor level. Repression of GSK3ß activity reduces Drosha activity towards pri-miRs, leading to accumulation of unprocessed pri-miRs and reduction of mature pri-miRs without altering levels or cellular locations of miR biogenesis proteins...
AU  - Fletcher,CE
AU  - Godfrey,JD
AU  - Shibakawa,A
AU  - Bushell,M
AU  - Bevan,CL
DO  - nar/gkw938
EP  - 2828
PY  - 2017///
SN  - 2159-3345
SP  - 2809
TI  - A novel role for GSK3β as a modulator of Drosha microprocessor activity and MicroRNA biogenesis
T2  - Nucleic Acid Research
UR  - http://dx.doi.org/10.1093/nar/gkw938
UR  - http://hdl.handle.net/10044/1/41279
VL  - 45
ER  -
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