|2021-||Director of Postgraduate Studies|
|2018-2021||Postgraduate Admissions Tutor|
|2012-2018||Departmental Athena SWAN Coordinator|
|2007-2021||Lecturer/Senior Lecturer/Reader in Chemical Engineering (Lonza/RCUK Academic Fellowship)|
|2006-2007||Research and Development Scientist, Lonza Biologics|
|2007||PhD in Chemical Engineering, Imperial College London.
An Integrated Modelling/Experimental Framework for Protein-producing Animal Cell Cultures.
|2002||MEng in Chemical Engineering, Imperial College London|
My interests lie in the area of biotechnology, with particular focus on the application of systems engineering principles to bioprocessing. My research involves the systematic integration of model-based tools, such as sensitivity analysis, design of experiments and optimisation, with experimentation on mammalian cell culture systems. Topics of interest include optimisation of culture media and conditions productivity, protein glycosylation, metabolic flux analysis and multiscale modelling.
Interested in our work on vaccine manufacturing?
How fast can we make 8 billion doses of RNA vaccine? What are the necessary resources? Read the latest Public Citizen report co-authored by Dr Zoltan Kis here.
The DELVE report on SARS-CoV-2 vaccine development and implementation is now available online.
You can also read our latest articles on the topic on Imperial's website and in The Engineer. Dr Zoltan Kis has also contributed to articles in Politico, Chemistry World and Wired, the latter focussing on RNA vaccines.
Not a scientist? Have a look at this short video
- New PhD opportunity on modelling microbial communities in collaboration with Dr Samraat Pawar and Dr Rodrigo Ledesma-Amaro. Full details on the project and how to apply can be found here.
- Read our latest evaluation of viral vector and RNA vaccine manufacturing platforms here.
- Together with the group of Dr Ioscani Jimenez del Val at University College Dublin, we have developed CHOmpact, a small-scale stoichiometric model of CHO cell metabolism accompanied by novel flux balance solution methodologies. CHOmpact can accurately describe all cell culture phases and offers enhanced interpretability of results. The preprint is available here.
- Our work on hybrid data-driven/mechanistic modelling of Bioprocesses is featured in Genetic Engineering & Biotechnology News.
et al., 2013, An optimised method for extraction and quantification of nucleotides and nucleotide sugars from mammalian cells, Analytical Biochemistry, Vol:443, Pages:172-180
et al., 2012, Genome-based kinetic modeling of cytosolic glucosemetabolism in industrially relevant cell lines -Saccharomyces cerevisiae and Chinese hamsterovary cells, Bioprocess and Biosystems Engineering, Vol:35, Pages:1023-1033
Kontoravdi C, Pistikopoulos EN, Mantalaris A, 2010, Systematic development of predictive mathematical models for animal cell cultures, Computers & Chemical Engineering, Vol:34, Pages:1192-1198