Imperial College London
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DrCosettaMinelli

Faculty of Medicine, National Heart & Lung Institute

Emeritus Reader in Medical Statistics
 
 
 
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Contact

 

cosetta.minelli1 Website

 
 
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Location

 

G 49Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Accordini:2020:10.1038/s41598-020-60478-5,
author = {Accordini, S and Calciano, L and Marcon, A and Pesce, G and Antó, JM and Beckmeyer-Borowko, AB and Carsin, A-E and Corsico, AG and Imboden, M and Janson, C and Keidel, D and Locatelli, F and Svanes, C and Burney, PGJ and Jarvis, D and Probst-Hensch, NM and Minelli, C},
doi = {10.1038/s41598-020-60478-5},
journal = {Scientific Reports},
title = {Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study},
url = {http://dx.doi.org/10.1038/s41598-020-60478-5},
volume = {10},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Investigating COPD trends may help healthcare providers to forecast future disease burden. We estimated sex- and smoking-specific incidence trends of pre-bronchodilator airflow obstruction (AO) among adults without asthma from 11 European countries within a 20-year follow-up (ECRHS and SAPALDIA cohorts). We also quantified the extent of misclassification in the definition based on pre-bronchodilator spirometry (using post-bronchodilator measurements from a subsample of subjects) and we used this information to estimate the incidence of post-bronchodilator AO (AOpost-BD), which is the primary characteristic of COPD. AO incidence was 4.4 (95% CI: 3.5-5.3) male and 3.8 (3.1-4.6) female cases/1,000/year. Among ever smokers (median pack-years: 20, males; 12, females), AO incidence significantly increased with ageing in men only [incidence rate ratio (IRR), 1-year increase: 1.05 (1.03-1.07)]. A strong exposure-response relationship with smoking was found both in males [IRR, 1-pack-year increase: 1.03 (1.02-1.04)] and females [1.03 (1.02-1.05)]. The positive predictive value of AO for AOpost-BD was 59.1% (52.0-66.2%) in men and 42.6% (35.1-50.1%) in women. AOpost-BD incidence was 2.6 (1.7-3.4) male and 1.6 (1.0-2.2) female cases/1,000/year. AO incidence was considerable in Europe and the sex-specific ageing-related increase among ever smokers was strongly related to cumulative tobacco exposure. AOpost-BD incidence is expected to be half of AO incidence.
AU  - Accordini,S
AU  - Calciano,L
AU  - Marcon,A
AU  - Pesce,G
AU  - Antó,JM
AU  - Beckmeyer-Borowko,AB
AU  - Carsin,A-E
AU  - Corsico,AG
AU  - Imboden,M
AU  - Janson,C
AU  - Keidel,D
AU  - Locatelli,F
AU  - Svanes,C
AU  - Burney,PGJ
AU  - Jarvis,D
AU  - Probst-Hensch,NM
AU  - Minelli,C
DO  - 10.1038/s41598-020-60478-5
PY  - 2020///
SN  - 2045-2322
TI  - Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-020-60478-5
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32103063
UR  - http://hdl.handle.net/10044/1/77964
VL  - 10
ER  -
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