Imperial College London


Faculty of MedicineDepartment of Immunology and Inflammation

Professor of Immunology



+44 (0)20 3313 8212d.altmann




5S5CHammersmith HospitalHammersmith Campus





Danny Altmann heads a lab at the Hammersmith Hospital Campus of Imperial, with expertise in the HLA system, antigen discovery, T cell subsets and NK cells. Key research interests are the immunology of  infectious disease including severe bacterial infections, Zika virus and Chikungunya virus. Other projects focus on autoimmune disease including the role of the microbiota in rheumatoid arthritis and autoimmune immunotoxicity in cancer immunotherapy. He serves as editor for a number of journals and has roles with a number of funding organisations.

Selected Publications

Journal Articles

Swadling L, Diniz MO, Schmidt NM, et al., 2021, Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2, Nature, Vol:601, ISSN:0028-0836, Pages:110-117

Boyton RJ, Altmann DM, 2021, The immunology of asymptomatic SARS-CoV-2 infection: what are the key questions?, Nature Reviews Immunology, Vol:21, ISSN:1474-1733, Pages:762-768

Gupta RK, Rosenheim J, Bell LC, et al., 2021, Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study., The Lancet Microbe, Vol:2, ISSN:2666-5247, Pages:e508-e517

Reynolds CJ, Pade C, Gibbons JM, et al., 2021, Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose, Science, Vol:372, ISSN:0036-8075, Pages:1418-1423

Altmann DM, Reynolds CJ, Boyton RJ, 2021, SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition., Cell Reports Medicine, Vol:2, ISSN:2666-3791, Pages:1-3

McDonald I, Murray S, Reynolds C, et al., 2021, Comparative systematic review and meta-analysis of reactogenicity, immunogenicity and efficacy of vaccines against SARS-CoV-2, Npj Vaccines, Vol:6, ISSN:2059-0105

Manisty C, Otter AD, Treibel TA, et al., 2021, Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals, The Lancet, Vol:397, ISSN:0140-6736, Pages:1057-1058

Adrielle Dos Santos L, Filho PGDG, Silva AMF, et al., 2021, Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers, Journal of Infection, Vol:82, ISSN:0163-4453, Pages:399-406

Reynolds CJ, Swadling L, Gibbons JM, et al., 2020, Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection., Science Immunology, Vol:5, ISSN:2470-9468, Pages:1-19

Gregorova M, Morse D, Brignoli T, et al., 2020, Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring AMR bacterial pneumonia, Elife, Vol:9, ISSN:2050-084X

Altmann DM, Boyton RJ, 2020, SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection, Science Immunology, Vol:5, ISSN:2470-9468

Altmann DM, Douek DC, Boyton RJ, 2020, What policy makers need to know about COVID-19 protective immunity, The Lancet, Vol:395, ISSN:0140-6736, Pages:1527-1529

Reynolds CJ, Watber P, Santos CNO, et al., 2020, Strong CD4 T cell responses to Zika virus antigens in a cohort of Dengue virus immune mothers of congenital Zika virus syndrome infants, Frontiers in Immunology, Vol:11, ISSN:1664-3224

Pinato DJ, Gramenitskaya D, Altmann DM, et al., 2019, Antibiotic therapy and outcome from immune-checkpoint inhibitors, Journal for Immunotherapy of Cancer, Vol:7, ISSN:2051-1426

Boyton RJ, Altmann DM, 2019, Muco-obstructive lung diseases, New England Journal of Medicine, Vol:381, ISSN:0028-4793, Pages:E20-+

Chambers E, Byrne C, Morrison D, et al., 2019, Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial, Gut, Vol:68, ISSN:0017-5749, Pages:1430-1438

Sim M, Rajagopalan S, Altmann D, et al., 2019, Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C, Proceedings of the National Academy of Sciences of the United States of America, Vol:116, ISSN:0027-8424, Pages:12964-12973

Altmann DM, 2019, "Just 17 if you know what I mean' ... but what do we really mean to say about Th17 immunity?, Immunology, Vol:156, ISSN:0019-2805, Pages:297-298

Nithichanon A, Rinchai D, Buddhisa S, et al., 2018, Immune control of Burkholderia pseudomallei––common, high-frequency T-cell responses to a broad repertoire of immunoprevalent epitopes, Frontiers in Immunology, Vol:9, ISSN:1664-3224

Altmann D, 2018, Don't let peer review panels for grant awards turn into a wolf pack., Nature, Vol:555, Pages:311-311

Reynolds CJ, Suleyman OM, Ortega-Prieto AM, et al., 2018, T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses, Scientific Reports, Vol:8, ISSN:2045-2322

Lima Keesen TS, de Almeida RP, Gois BM, et al., 2017, Guillain-Barre syndrome and arboviral infection in Brazil, Lancet Infectious Diseases, Vol:17, ISSN:1473-3099, Pages:693-694

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