Publications
272 results found
Ellmerich S, Takacs K, Mycko M, et al., 2004, Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 34, Pages: 1839-1848, ISSN: 0014-2980
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- Citations: 41
Boyton RJ, Altmann DM, 2004, Asthma: new developments in cytokine regulation, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 136, Pages: 13-14, ISSN: 0009-9104
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- Citations: 12
Llewelyn M, Sriskandan S, Peakman M, et al., 2004, HLA class II polymorphisms determine responses to bacterial superantigens, JOURNAL OF IMMUNOLOGY, Vol: 172, Pages: 1719-1726, ISSN: 0022-1767
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- Citations: 74
Altmann DM, Boyton RJ, 2004, Models of multiple sclerosis, Drug Discovery Today: Disease Models, Vol: 1, Pages: 405-410, ISSN: 1740-6757
Multiple sclerosis, the most common disease of central nervous system demyelination, is widely believed to result from autoimmune attack of myelin by T lymphocytes. Several approaches are widely used to model the disease. In vitro studies address specific steps in disease such as mechanisms of T-cell activation by myelin epitopes, migration across the blood-brain barrier and demyelination. In vivo models encompass approaches based on experimental allergic encephalomyelitis, as well as transgenic and mutant strains. Using these models, many therapeutic strategies have been proposed. © 2004 Elsevier Ltd. All rights reserved.
Altmann DM, Boyton RJ, 2003, Reciprocal conditioning: T cells as regulators of dendritic cell function, IMMUNOLOGY, Vol: 109, Pages: 473-475, ISSN: 0019-2805
Boyton RJ, Altmann DM, 2002, Is selection for TCR affinity a factor in cytokine polarization?, TRENDS IN IMMUNOLOGY, Vol: 23, Pages: 526-529, ISSN: 1471-4906
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- Citations: 50
Unnikrishnan M, Altmann DM, Proft T, et al., 2002, The bacterial superantigen streptococcal mitogenic exotoxin Z is the major immunoactive agent of <i>Streptococcus pyogenes</i>, JOURNAL OF IMMUNOLOGY, Vol: 169, Pages: 2561-2569, ISSN: 0022-1767
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- Citations: 69
Boyton RJ, Zaccai N, Jones EY, et al., 2002, CD4 T cells selected by antigen under Th2 polarizing conditions favor an elongated TCRα chain complementarity-determining region 3, JOURNAL OF IMMUNOLOGY, Vol: 168, Pages: 1018-1027, ISSN: 0022-1767
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- Citations: 16
Boyton RJ, Altmann DM, 2002, Transgenic models of autoimmune disease, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 127, Pages: 4-11, ISSN: 0009-9104
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- Citations: 18
Sriskandan S, Unnikrishnan M, Krausz T, et al., 2001, Enhanced susceptibility to superantigen-associated streptococcal sepsis in human leukocyte antigen-DQ transgenic mice, JOURNAL OF INFECTIOUS DISEASES, Vol: 184, Pages: 166-173, ISSN: 0022-1899
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- Citations: 61
Perraudeau M, Taylor PR, Stauss HJ, et al., 2000, Altered major histocompatibility complex class II peptide loading in H2-O-deficient mice, European Journal of Immunology, Vol: 30, Pages: 2871-2880, ISSN: 0014-2980
The biosynthesis of MHC class II/peptide complexes involves classical, cell surface MHC products as well as the intracellular component H2-M, required for the removal of invariant chain-derived CLIP and for peptide loading. The function of another intracellular class II heterodimer, H2-O, is the matter of some controversy. The physical association of H2-O with H2-M and co-localization in class II+ vesicles suggest a related function in peptide exchange. Furthermore, the distinctive thymic distribution of H2-O raises the possibility of a specialized role in T cell thymic selection. To investigate the role of H2-O in vivo we generated mice carrying a targeted disruption in the H2-Oa gene. No evidence was obtained for a defect in removal of CLIP. However, the array of endogenous peptides bound by class II was altered and a defect in antigen presentation through H2-A to T cells was seen on the 129/Sv/C57BL/6 mixed strain background but not in 129/Sv pure strain mice. Furthermore, H2-O-null mice showed enhanced selection of CD4+ single positive thymocytes. The findings indicate that H2-O interacts with H2-M in peptide editing but that the genetic background in which H2-O deficiency is manifest is also important. Overall, the experiments indicate that H2-O/HLA-DO should be regarded as neither up-regulating nor down-regulating the DM-dependent release of CLIP, but as a modulator of peptide editing, determining the presenting cell type specific peptide profile able to retain stability in the class II groove.
Perraudeau M, Taylor PR, Stauss HJ, et al., 2000, Altered major histocompatibility complex class II peptide loading in H2-O-deficient mice, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 30, Pages: 2871-2880, ISSN: 0014-2980
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- Citations: 42
Douek DC, Altmann DM, 2000, T-cell apoptosis and differential human leucocyte antigen class II expression in human thymus, IMMUNOLOGY, Vol: 99, Pages: 249-256, ISSN: 0019-2805
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- Citations: 32
Birk OS, Gur SL, Elias D, et al., 1999, The 60-kDa heat shock protein modulates allograft rejection, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 96, Pages: 5159-5163, ISSN: 0027-8424
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- Citations: 55
Boyton RJ, Lohmann T, Londei M, et al., 1998, Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to type I diabetes: analysis in disease discordant human twins, nonobese diabetic mice and HLA-DQ transgenic mice, INTERNATIONAL IMMUNOLOGY, Vol: 10, Pages: 1765-1776, ISSN: 0953-8178
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- Citations: 39
Takacs K, Altmann DM, 1998, The case against epitope spread in experimental allergic encephalomyelitis, IMMUNOLOGICAL REVIEWS, Vol: 164, Pages: 101-110, ISSN: 0105-2896
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- Citations: 11
Takacs K, Chandler P, Altmann DM, 1997, Relapsing and remitting experimental allergic encephalomyelitis: a focused response to the encephalitogenic peptide rather than epitope spread, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 27, Pages: 2927-2934, ISSN: 0014-2980
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- Citations: 28
Reizis B, Altmann DM, Cohen IR, 1997, Biochemical characterization of the human diabetes-associated HLA-DQ8 allelic product: similarity to the major histocompatibility complex class II I-A(g7) protein of non-obese diabetic mice, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 27, Pages: 2478-2483, ISSN: 0014-2980
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- Citations: 30
Elliott JI, Dewchand H, Altmann DM, 1997, Streptozotocin-induced diabetes in mice lacking alpha beta T cells, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 109, Pages: 116-120, ISSN: 0009-9104
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- Citations: 29
Newton SG, Altmann DM, 1997, Analysis of heat shock protein 60 epitopes in transgenic mice., BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 25, Pages: S308-S308, ISSN: 0300-5127
Lamikanra A, Gruneberg U, Altmann D, et al., 1997, Mutations to the alpha-2 domain of human class II molecules alters the efficiency of peptide loading and antigen presentation, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 25, Pages: S357-S357, ISSN: 0300-5127
Rosloniec EF, Brand DD, Myers LK, et al., 1997, An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 185, Pages: 1113-1122, ISSN: 0022-1007
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- Citations: 186
Douek DC, Altmann DM, 1997, HLA-DO is an intracellular class II molecule with distinctive thymic expression, INTERNATIONAL IMMUNOLOGY, Vol: 9, Pages: 355-364, ISSN: 0953-8178
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- Citations: 68
Elliott JI, Douek DC, Altmann DM, 1996, Mice lacking alpha beta(+) T cells are resistant to the induction of experimental autoimmune encephalomyelitis, JOURNAL OF NEUROIMMUNOLOGY, Vol: 70, Pages: 139-144, ISSN: 0165-5728
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- Citations: 15
Douek DC, Corley KTT, Zal T, et al., 1996, Negative selection by endogenous antigen and superantigen occurs at multiple thymic sites, INTERNATIONAL IMMUNOLOGY, Vol: 8, Pages: 1413-1420, ISSN: 0953-8178
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- Citations: 36
Elliott JI, Altmann DM, 1996, Non-obese diabetic mice hemizygous at the T cell receptor alpha locus are susceptible to diabetes and sialitis, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 26, Pages: 953-956, ISSN: 0014-2980
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- Citations: 25
Birk OS, Douek DC, Elias D, et al., 1996, A role of Hsp60 in autoimmune diabetes: Analysis in a transgenic model, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 93, Pages: 1032-1037, ISSN: 0027-8424
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- Citations: 101
TAKACS K, DOUEK DC, ALTMANN DM, 1995, EXACERBATED AUTOIMMUNITY ASSOCIATED WITH A T-HELPER-1 CYTOKINE PROFILE SHIFT IN H-2E-TRANSGENIC MICE, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 25, Pages: 3134-3141, ISSN: 0014-2980
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- Citations: 18
ELLIOTT JI, ALTMANN DM, 1995, DUAL T-CELL RECEPTOR ALPHA-CHAIN T-CELLS IN AUTOIMMUNITY, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 182, Pages: 953-959, ISSN: 0022-1007
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- Citations: 77
CHANDLER P, FRATER AJ, DOUEK DC, et al., 1995, IMMUNE RESPONSIVENESS IN MUTANT MICE LACKING T-CELL RECEPTOR ALPHA-BETA(+) CELLS, IMMUNOLOGY, Vol: 85, Pages: 531-537, ISSN: 0019-2805
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- Citations: 13
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