Imperial College London
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ProfessorDannyAltmann

Faculty of Medicine, Department of Immunology and Inflammation

Professor of Immunology
 
 
 
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Contact

 

+44 (0)20 3313 8212d.altmann

 
 
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Location

 

5S5CHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Guerra-Gomes:2021:10.1016/j.cyto.2021.155651,
author = {Guerra-Gomes, IC and Goisa, BM and Peixoto, RF and Palmeira, PHDS and Dias, CNDS and Csordas, BG and Araujo, JMG and Veras, RC and Medeiros, IAD and Azevedox, FDLAAD and Boyton, RJ and Altmann, DM and Keesen, TSL},
doi = {10.1016/j.cyto.2021.155651},
journal = {Cytokine},
pages = {1--7},
title = {Phenotypical characterization of regulatory T cells in acute Zika infection},
url = {http://dx.doi.org/10.1016/j.cyto.2021.155651},
volume = {146},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Zika virus (ZIKV), alongside Dengue virus (DENV), Chikungunya virus (CHIKV), and Yellow Fever Virus (YFV) are prevalent arboviruses in the Americas. Each of these infections is associated with the development of associated disease immunopathology. Immunopathological processes are an outcome of counter-balancing impacts between effector and regulatory immune mechanisms. In this context, regulatory T cells (Tregs) are key in modulating the immune response and, therefore, in tissue damage control. However, to date, Treg phenotypes and mechanisms during acute infection of the ZIKV in humans have not been fully investigated. The main aim of this work was to characterize Tregs and their immunological profile related to cytokine production and molecules that are capable of controlling the exacerbated inflammatory profile in acute Zika infected patients. Using whole blood analyses of infected patients, an ex vivo phenotypical characterization of Tregs, circulating during acute Zika virus infection, was conducted by flow cytometry. We found that though there are no differences in absolute Treg frequency between infected and healthy control groups. However, pro-inflammatory cytokine up-regulation such as IFN-γ and LAP was observed in the acute disease. Furthermore, acute ZIKV patients expressed increased levels of CD39/CD73, perforin/granzyme B, PD-1, and CTLA-4, all markers involved in mechanisms used by Tregs to attempt to control strong inflammatory responses. Thus, the data indicates a potential contribution of Tregs during the inflammatory ZIKV infection response.
AU  - Guerra-Gomes,IC
AU  - Goisa,BM
AU  - Peixoto,RF
AU  - Palmeira,PHDS
AU  - Dias,CNDS
AU  - Csordas,BG
AU  - Araujo,JMG
AU  - Veras,RC
AU  - Medeiros,IAD
AU  - Azevedox,FDLAAD
AU  - Boyton,RJ
AU  - Altmann,DM
AU  - Keesen,TSL
DO  - 10.1016/j.cyto.2021.155651
EP  - 7
PY  - 2021///
SN  - 1096-0023
SP  - 1
TI  - Phenotypical characterization of regulatory T cells in acute Zika infection
T2  - Cytokine
UR  - http://dx.doi.org/10.1016/j.cyto.2021.155651
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000684202400018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S1043466621002374?via%3Dihub
VL  - 146
ER  -
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