Imperial College London
Portrait Picture

DrDavidAntcliffe

Faculty of Medicine, Department of Surgery & Cancer

Clinical Senior Lecturer in Critical Medicine
 
 
 
//

Contact

 

d.antcliffe

 
 
//

Location

 

Intensive Care UnitCharing Cross HospitalCharing Cross Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Mi:2022:10.1101/2022.08.07.22278495,
author = {Mi, Y and Burnham, KL and Charles, PD and Heilig, R and Vendrell, I and Whalley, J and Torrance, HD and Antcliffe, DB and May, SM and Neville, MJ and Berridge, G and Hutton, P and Goh, C and Radhakrishnan, J and Nesvizhskii, A and Yu, F and Davenport, EE and McKechnie, S and Davies, R and OCallaghan, DJP and Patel, P and Karpe, F and Gordon, AC and Ackland, GL and Hinds, CJ and Fischer, R and Knight, JC},
doi = {10.1101/2022.08.07.22278495},
title = {High-throughput mass spectrometry maps the sepsis plasma proteome and differences in response},
url = {http://dx.doi.org/10.1101/2022.08.07.22278495},
year = {2022}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Summary</jats:title><jats:p>Sepsis, the dysregulated host response to infection causing life-threatening organ dysfunction, is an unmet global health challenge. Here we apply high-throughput tandem mass spectrometry to delineate the plasma proteome for sepsis and comparator groups (non-infected critical illness, post-operative inflammation and healthy volunteers) involving 2622 samples and 4553 liquid chromatography-mass spectrometry analyses in a single batch, at 100 samples/day. We show how this scale of data can establish shared and specific proteins, pathways and co-expression modules in sepsis, and be integrated with paired leukocyte transcriptomic data (n=837 samples) using matrix decomposition. We map the landscape of the host response in sepsis including changes over time, and identify features relating to etiology, clinical phenotypes and severity. This work reveals novel subphenotypes informative for sepsis response state, disease processes and outcome, highlights potential biomarkers, pathways and processes for drug targets, and advances a systems-based precision medicine approach to sepsis.</jats:p>
AU  - Mi,Y
AU  - Burnham,KL
AU  - Charles,PD
AU  - Heilig,R
AU  - Vendrell,I
AU  - Whalley,J
AU  - Torrance,HD
AU  - Antcliffe,DB
AU  - May,SM
AU  - Neville,MJ
AU  - Berridge,G
AU  - Hutton,P
AU  - Goh,C
AU  - Radhakrishnan,J
AU  - Nesvizhskii,A
AU  - Yu,F
AU  - Davenport,EE
AU  - McKechnie,S
AU  - Davies,R
AU  - OCallaghan,DJP
AU  - Patel,P
AU  - Karpe,F
AU  - Gordon,AC
AU  - Ackland,GL
AU  - Hinds,CJ
AU  - Fischer,R
AU  - Knight,JC
DO  - 10.1101/2022.08.07.22278495
PY  - 2022///
TI  - High-throughput mass spectrometry maps the sepsis plasma proteome and differences in response
UR  - http://dx.doi.org/10.1101/2022.08.07.22278495
ER  -
Download