136 results found
Kobeissi E, Hibino M, Pan H, et al., 2019, Blood pressure, hypertension and the risk of abdominal aortic aneurysms: a systematic review and meta-analysis of cohort studies., Eur J Epidemiol, Vol: 34, Pages: 547-555
Abdominal aortic aneurysms (AAA) are fatal in 80% of the cases when ruptured. Hypertension has been considered a potential risk factor for AAA; but the findings from prospective cohort studies have not been entirely consistent, nor have they been summarised in a comprehensive meta-analysis. Our aim was to conduct a systematic review and meta-analysis of cohort studies of the association between blood pressure, hypertension and AAA to clarify the strength and shape of these associations. We searched PubMed and Embase databases for relevant cohort studies up to April 30th, 2018. Random-effects models were used to calculate summary relative risks (RRs) and 95% confidence intervals (CIs). The meta-analysis included 21 cohort studies (20 publications) with data on 28,162 cases and 5,440,588 participants. The findings indicate that the RR of AAA in hypertensive patients is 1.66 times (95% CI: 1.49-1.85, I2 = 79.3%, n = 13) that of non-hypertensive patients. In addition, there was a 14% (95% CI: 6-23%, I2 = 30.5%, n = 6) and a 28% (95% CI: 12-46%, I2 = 80.1%, n = 6) increase in the RR of AAA for every 20 mmHg and 10 mmHg increase in systolic blood pressure (SBP) and diastolic blood pressure (DBP), respectively. The analysis of DBP showed evidence of a strong and highly significant nonlinear dose-response relationship (p < 0.001) with a steeper association from 80 mmHg and above. This meta-analysis suggests that hypertension increases the risk of developing AAA by 66%. Further studies are needed to clarify the underlying mechanism explaining the much stronger association between DBP and AAA than for SBP.
Aune D, Sen A, Norat T, et al., 2019, Dietary fibre intake and the risk of diverticular disease: a systematic review and meta-analysis of prospective studies., Eur J Nutr
BACKGROUND: A high intake of dietary fibre has been associated with a reduced risk of diverticular disease in several studies; however, the dose-response relationship between fibre intake and diverticular disease risk has varied, and the available studies have not been summarised in a meta-analysis. We conducted a systematic review and meta-analysis of prospective cohort studies to clarify the association between dietary fibre intake, fibre subtypes, and the risk of diverticular disease. METHODS: PubMed and Embase databases were searched up to August 9th 2018. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated using a random-effects model and nonlinear associations were modelled using fractional polynomial models. RESULTS: Five prospective cohort studies with 19,282 cases and 865,829 participants were included in the analysis of dietary fibre and diverticular disease risk. The summary RR was 0.74 (95% CI 0.71-0.78, I2 = 0%) per 10 g/day. There was no evidence of a nonlinear association between dietary fibre intake and diverticular disease risk, pnonlinearity = 0.35, and there was a 23%, 41% and 58% reduction in risk for an intake of 20, 30, and 40 g/day, respectively, compared to 7.5 g/day. There was no evidence of publication bias with Egger's test, p = 0.58 and the association persisted in subgroup and sensitivity analyses. The summary RR per 10 g/day was 0.74 (95% CI 0.67-0.81, I2 = 60%, n = 4) for cereal fibre, 0.56 (95% CI 0.37-0.84, I2 = 73%, n = 2) for fruit fibre, and 0.80 (95% CI 0.45-1.44, I2 = 87%, n = 2) for vegetable fibre. CONCLUSIONS: These results suggest that a high fibre intake may reduce the risk of diverticular disease and individuals consuming 30 g of fibre per day have a 41% reduction in risk compared to persons with a low fibre intake. Further studies are needed on f
Park JY, Bueno-de-Mesquita HB, Ferrari P, et al., 2019, Dietary folate intake and pancreatic cancer risk: Results from the European prospective investigation into cancer and nutrition, INTERNATIONAL JOURNAL OF CANCER, Vol: 144, Pages: 1511-1521, ISSN: 0020-7136
Bradbury KE, Appleby PN, Tipper SJ, et al., 2019, Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition, INTERNATIONAL JOURNAL OF CANCER, Vol: 144, Pages: 957-966, ISSN: 0020-7136
Perez-Cornago A, Huybrechts I, Appleby PN, et al., 2019, Intake of individual fatty acids and risk of prostate cancer in the European prospective investigation into cancer and nutrition., Int J Cancer
The associations of individual dietary fatty acids with prostate cancer risk have not been examined comprehensively. We examined the prospective association of individual dietary fatty acids with prostate cancer risk overall, by tumor subtypes, and prostate cancer death. 142,239 men from the European Prospective Investigation into Cancer and Nutrition who were free from cancer at recruitment were included. Dietary intakes of individual fatty acids were estimated using center-specific validated dietary questionnaires at baseline and calibrated with 24-h recalls. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average follow-up of 13.9 years, 7,036 prostate cancer cases and 936 prostate cancer deaths were ascertained. Intakes of individual fatty acids were not related to overall prostate cancer risk. There was evidence of heterogeneity in the association of some short chain saturated fatty acids with prostate cancer risk by tumor stage (pheterogeneity < 0.015), with a positive association with risk of advanced stage disease for butyric acid (4:0; HR1SD = 1.08; 95%CI = 1.01-1.15; p-trend = 0.026). There were no associations with fatal prostate cancer, with the exception of a slightly higher risk for those who consumed more eicosenoic acid (22:1n-9c; HR1SD = 1.05; 1.00-1.11; p-trend = 0.048) and eicosapentaenoic acid (20:5n-3c; HR1SD = 1.07; 1.00-1.14; p-trend = 0.045). There was no evidence that dietary intakes of individual fatty acids were associated with overall prostate cancer risk. However, a higher intake of butyric acid might be associated with a higher risk of advanced, whereas intakes of eicosenoic and eicosapentaenoic acids might be positively associated with fatal prostate cancer risk.
Abar L, Sobiecki JG, Cariolou M, et al., 2019, Body size and obesity during adulthood, and risk of lympho-hematopoietic cancers: an update of the WCRF-AICR systematic review of published prospective studies., Ann Oncol
Background: To summarise the evidence on the associations between body mass index (BMI) and BMI in early adulthood, height, waist circumference (WC) and waist to hip ratio (WHR), and risk of lympho-hematopoietic cancers. Method: We conducted a meta-analysis of prospective studies and identified relevant studies published up to December 2017 by searching PubMed. A random effects model was used to calculate dose-response summary relative risks (RRs). Results: Our findings showed BMI, and BMI in early adulthood (aged 18-21 years) is associated with the risk of Hodgkin's and Non-Hodgkin's lymphoma (HL and NHL), Diffuse Large Beta Cell Lymphoma (DLBCL), Leukaemia including Acute and Chronic Myeloid Lymphoma (AML and CML), and Chronic Lymphocytic Leukaemia (CLL) and Multiple Myeloma. The summary RR per 5 kg/m2 increase in BMI were 1.12 (95% CI: 1.05-1.20) for HL, 1.05 (95% CI:1.03-1.08) for NHL, 1.11 (95% CI:1.05-1.16) for DLBCL, 1.06 (95% CI:1.03-1.09) for ML, 1.09 (95% CI:1.03-1.15) for leukaemia, 1.13 (95% CI:1.04-1.24) for AML, 1.13 (95% CI:1.05-1.22) for CML and 1.04 (95% CI:1.00-1.09) for CLL, and were1.12 (95% CI:1.05-1.19) for NHL, 1.22 (95% CI:1.09-1.37) for DLBCL, and 1.19 (95% CI:1.03-1.38) for FL for BMI in early adulthood analysis.Results on mortality showed a 15%, 16% and 17% increased risk of NHL, multiple myeloma and leukaemia, respectively. Greater height increased the risk of NHL by 7%, DLBCL by 10%, FL by 9%, multiple myeloma by 5%, and Leukaemia by 7%. WHR was associated with increased risk of DLBCL by 12%. No association was found between higher WC and risk of multiple myeloma. Conclusion: Our results revealed that general adiposity in adulthood and early adulthood, and greater height may increase the risk of almost all types of lympho-hematopoietic cancers and this adds to a growing body of evidence linking body fatness to several types of cancers.
Aasdahl L, Iversen VM, Skovlund E, et al., 2019, What should be the preferred exercise modality for overweight and obese individuals? Protocol for a systematic review and network meta-analysis, SYSTEMATIC REVIEWS, Vol: 8, ISSN: 2046-4053
Feng T, Vegard M, Strand LB, et al., 2019, Metabolically Healthy Obesity and Risk for Atrial Fibrillation: The HUNT Study, OBESITY, Vol: 27, Pages: 332-338, ISSN: 1930-7381
Aune D, Schlesinger S, Norat T, et al., 2019, Tobacco smoking and the risk of heart failure: A systematic review and meta-analysis of prospective studies, EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, Vol: 26, Pages: 279-288, ISSN: 2047-4873
Huseinovic E, Winkvist A, Freisling H, et al., 2019, Timing of eating across ten European countries - results from the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study, PUBLIC HEALTH NUTRITION, Vol: 22, Pages: 324-335, ISSN: 1368-9800
Gasull M, Pumarega J, Kiviranta H, et al., 2019, Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort, ENVIRONMENTAL RESEARCH, Vol: 169, Pages: 417-433, ISSN: 0013-9351
Sen A, Papadimitriou N, Lagiou P, et al., 2019, Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition, INTERNATIONAL JOURNAL OF CANCER, Vol: 144, Pages: 240-250, ISSN: 0020-7136
Ward HA, Murphy N, Weiderpass E, et al., 2018, Gallstones and incident colorectal cancer in a large pan-European cohort study., Int J Cancer
Gallstones, a common gastrointestinal condition, can lead to several digestive complications and can result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking and physical inactivity, all of which are known risk factors for colorectal cancer (CRC), as is inflammation. However, it is unclear whether gallstones are a risk factor for CRC. We examined the association between history of gallstones and CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a prospective cohort of over half a million participants from ten European countries. History of gallstones was assessed at baseline using a self-reported questionnaire. The analytic cohort included 334,986 participants; a history of gallstones was reported by 3,917 men and 19,836 women, and incident CRC was diagnosed among 1,832 men and 2,178 women (mean follow-up: 13.6 years). Hazard ratios (HR) and 95% confidence intervals (CI) for the association between gallstones and CRC were estimated using Cox proportional hazards regression models, stratified by sex, study centre and age at recruitment. The models were adjusted for body mass index, diabetes, alcohol intake and physical activity. A positive, marginally significant association was detected between gallstones and CRC among women in multivariable analyses (HR = 1.14, 95%CI 0.99-1.31, p = 0.077). The relationship between gallstones and CRC among men was inverse but not significant (HR = 0.81, 95%CI 0.63-1.04, p = 0.10). Additional adjustment for details of reproductive history or waist circumference yielded minimal changes to the observed associations. Further research is required to confirm the nature of the association between gallstones and CRC by sex.
Zamora-Ros R, Alghamdi MA, Cayssials V, et al., 2018, Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study., Eur J Nutr
PURPOSE: Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study. METHODS: The study was conducted in the EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, which included 476,108 adult men and women. Coffee and tea intakes were assessed through validated country-specific dietary questionnaires. RESULTS: During a mean follow-up of 14 years, 748 first incident differentiated TC cases (including 601 papillary and 109 follicular TC) were identified. Coffee consumption (per 100 mL/day) was not associated either with total differentiated TC risk (HRcalibrated 1.00, 95% CI 0.97-1.04) or with the risk of TC subtypes. Tea consumption (per 100 mL/day) was not associated with the risk of total differentiated TC (HRcalibrated 0.98, 95% CI 0.95-1.02) and papillary tumor (HRcalibrated 0.99, 95% CI 0.95-1.03), whereas an inverse association was found with follicular tumor risk (HRcalibrated 0.90, 95% CI 0.81-0.99), but this association was based on a sub-analysis with a small number of cancer cases. CONCLUSIONS: In this large prospective study, coffee and tea consumptions were not associated with TC risk.
Li K, Anderson G, Viallon V, et al., 2018, Risk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts, BREAST CANCER RESEARCH, Vol: 20, ISSN: 1465-542X
Aune D, Schlesinger S, Norat T, et al., 2018, Diabetes mellitus and the risk of abdominal aortic aneurysm: A systematic review and meta-analysis of prospective studies, JOURNAL OF DIABETES AND ITS COMPLICATIONS, Vol: 32, Pages: 1169-1174, ISSN: 1056-8727
Aune D, Snekvik I, Schlesinger S, et al., 2018, Body mass index, abdominal fatness, weight gain and the risk of psoriasis: a systematic review and dose-response meta-analysis of prospective studies, EUROPEAN JOURNAL OF EPIDEMIOLOGY, Vol: 33, Pages: 1163-1178, ISSN: 0393-2990
Lin C, Travis RC, Appleby PN, et al., 2018, Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition, INTERNATIONAL JOURNAL OF CANCER, Vol: 143, Pages: 2351-2358, ISSN: 0020-7136
Aune D, Schlesinger S, Neuenschwander M, et al., 2018, Diabetes mellitus, blood glucose and the risk of heart failure: A systematic review and meta-analysis of prospective studies, NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, Vol: 28, Pages: 1081-1091, ISSN: 0939-4753
Aune D, Mahamat-Saleh Y, Norat T, et al., 2018, Body fatness, diabetes, physical activity and risk of kidney stones: a systematic review and meta-analysis of cohort studies, EUROPEAN JOURNAL OF EPIDEMIOLOGY, Vol: 33, Pages: 1033-1047, ISSN: 0393-2990
Aune D, Keum N, Giovannucci E, et al., 2018, Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 108, Pages: 1069-1091, ISSN: 0002-9165
Sarink D, Schock H, Johnson T, et al., 2018, Receptor activator of nuclear factor kB ligand, osteoprotegerin, and risk of death following a breast cancer diagnosis: results from the EPIC cohort, BMC CANCER, Vol: 18, ISSN: 1471-2407
Aune D, Schlesinger S, Norat T, et al., 2018, Tobacco smoking and the risk of abdominal aortic aneurysm: a systematic review and meta-analysis of prospective studies, SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322
Freisling H, Noh H, Slimani N, et al., 2018, Nut intake and 5-year changes in body weight and obesity risk in adults: results from the EPIC-PANACEA study, EUROPEAN JOURNAL OF NUTRITION, Vol: 57, Pages: 2399-2408, ISSN: 1436-6207
Cairat M, Fournier A, Murphy N, et al., 2018, Nonsteroidal anti-inflammatory drug use and breast cancer risk in a European prospective cohort study, INTERNATIONAL JOURNAL OF CANCER, Vol: 143, Pages: 1688-1695, ISSN: 0020-7136
Aune D, 2018, Can nut consumption improve colon cancer survival?, TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY, Vol: 3, ISSN: 2224-476X
Aune D, Schlesinger S, Norat T, et al., 2018, Tobacco smoking and the risk of atrial fibrillation: A systematic review and meta-analysis of prospective studies, EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, Vol: 25, Pages: 1437-1451, ISSN: 2047-4873
Abar L, Vieira AR, Aune D, et al., 2018, Height and body fatness and colorectal cancer risk: an update of the WCRF-AICR systematic review of published prospective studies, EUROPEAN JOURNAL OF NUTRITION, Vol: 57, Pages: 1701-1720, ISSN: 1436-6207
Aune D, Schlesinger S, Norat T, et al., 2018, Body mass index, abdominal fatness, and the risk of sudden cardiac death: a systematic review and dose-response meta-analysis of prospective studies, EUROPEAN JOURNAL OF EPIDEMIOLOGY, Vol: 33, Pages: 711-722, ISSN: 0393-2990
Kaaks R, Fortner RT, Huesing A, et al., 2018, Tumor-associated autoantibodies as early detection markers for ovarian cancer? A prospective evaluation, INTERNATIONAL JOURNAL OF CANCER, Vol: 143, Pages: 515-526, ISSN: 0020-7136
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.