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@article{Park:2019:10.1002/ijc.31830,
author = {Park, JY and Bueno-de-Mesquita, HB and Ferrari, P and Weiderpass, E and de, Batlle J and Tjønneland, A and Kyro, C and Rebours, V and Boutron-Ruault, M-C and Mancini, FR and Katzke, V and Kühn, T and Boeing, H and Trichopoulou, A and La, Vecchia C and Kritikou, M and Masala, G and Pala, V and Tumino, R and Panico, S and Peeters, PH and Skeie, G and Merino, S and Duell, EJ and Rodríguez-Barranco, M and Dorronsoro, M and Chirlaque, M-D and Ardanaz, E and Gylling, B and Schneede, J and Ericson, U and Sternby, H and Khaw, K-T and Bradbury, KE and Huybrechts, I and Aune, D and Vineis, P and Slimani, N},
doi = {10.1002/ijc.31830},
journal = {International Journal of Cancer},
pages = {1511--1521},
title = {Dietary folate intake and pancreatic cancer risk: results from the European Prospective Investigation into Cancer and Nutrition},
url = {http://dx.doi.org/10.1002/ijc.31830},
volume = {144},
year = {2019}
}

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TY  - JOUR
AB  - Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/d) compared with the lowest (<241 μg/d) was 0.81 (95% CI: 0.51, 1.31; Ptrend = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles (HR=4.42 (95% CI: 1.05, 18.62) for ≥353 μg/d vs. <241 μg/d, Ptrend = 0.01). Nonetheless, there was no significant interaction between smoking and dietary folate intake (Pinteraction = 0.99). We found no association between dietary folate intake and PC risk in this large European study.
AU  - Park,JY
AU  - Bueno-de-Mesquita,HB
AU  - Ferrari,P
AU  - Weiderpass,E
AU  - de,Batlle J
AU  - Tjønneland,A
AU  - Kyro,C
AU  - Rebours,V
AU  - Boutron-Ruault,M-C
AU  - Mancini,FR
AU  - Katzke,V
AU  - Kühn,T
AU  - Boeing,H
AU  - Trichopoulou,A
AU  - La,Vecchia C
AU  - Kritikou,M
AU  - Masala,G
AU  - Pala,V
AU  - Tumino,R
AU  - Panico,S
AU  - Peeters,PH
AU  - Skeie,G
AU  - Merino,S
AU  - Duell,EJ
AU  - Rodríguez-Barranco,M
AU  - Dorronsoro,M
AU  - Chirlaque,M-D
AU  - Ardanaz,E
AU  - Gylling,B
AU  - Schneede,J
AU  - Ericson,U
AU  - Sternby,H
AU  - Khaw,K-T
AU  - Bradbury,KE
AU  - Huybrechts,I
AU  - Aune,D
AU  - Vineis,P
AU  - Slimani,N
DO  - 10.1002/ijc.31830
EP  - 1521
PY  - 2019///
SN  - 0020-7136
SP  - 1511
TI  - Dietary folate intake and pancreatic cancer risk: results from the European Prospective Investigation into Cancer and Nutrition
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.31830
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30178496
UR  - http://hdl.handle.net/10044/1/62841
VL  - 144
ER  -

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