Imperial College London
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DrDagfinnAune

Faculty of Medicine, School of Public Health

Research Associate
 
 
 
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Contact

 

+44 (0)20 7594 8478d.aune

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Aune:2018:10.1016/j.jdiacomp.2018.09.009,
author = {Aune, D and Schlesinger, S and Norat, T and Riboli, E},
doi = {10.1016/j.jdiacomp.2018.09.009},
journal = {Journal of Diabetes and its Complications},
pages = {1169--1174},
title = {Diabetes mellitus and the risk of abdominal aortic aneurysm: A systematic review and meta-analysis of prospective studies},
url = {http://dx.doi.org/10.1016/j.jdiacomp.2018.09.009},
volume = {32},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Diabetes mellitus has been associated with reduced risk of abdominal aortic aneurysm in a number of epidemiological studies, however, until recently little data from prospective studies have been available. We therefore conducted a systematic review and meta-analysis of prospective studies to quantify the association. MATERIAL AND METHODS: Two investigators searched the PubMed and Embase databases for studies of diabetes and abdominal aortic aneurysm up to May 8th 2018. Prospective studies were included if they reported adjusted relative risk (RR) estimates and 95% confidence intervals (95% CIs) of abdominal aortic aneurysm associated with a diabetes diagnosis. Summary relative risks were estimated by use of a random effects model. RESULTS: We identified 16 prospective studies with 16,572 cases among 4,563,415 participants that could be included in the meta-analysis. The summary RR for individuals with diabetes compared to individuals without diabetes was 0.58 (95% CI: 0.51-0.66, I2=40.4%, pheterogeneity=0.06). The results persisted when stratified by sex, duration of follow-up, and in most of the other subgroup analyses. There was no evidence of publication bias with Egger's test, p=0.64 or by inspection of the funnel plots. CONCLUSIONS: These results suggest that individuals with diabetes mellitus are at a reduced risk of abdominal aortic aneurysm, however, whether pharmacological agents for diabetes mellitus explain this observation needs to be clarified in future studies.
AU  - Aune,D
AU  - Schlesinger,S
AU  - Norat,T
AU  - Riboli,E
DO  - 10.1016/j.jdiacomp.2018.09.009
EP  - 1174
PY  - 2018///
SN  - 1056-8727
SP  - 1169
TI  - Diabetes mellitus and the risk of abdominal aortic aneurysm: A systematic review and meta-analysis of prospective studies
T2  - Journal of Diabetes and its Complications
UR  - http://dx.doi.org/10.1016/j.jdiacomp.2018.09.009
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30415876
UR  - http://hdl.handle.net/10044/1/64594
VL  - 32
ER  -
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