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@article{Abar:2019:annonc/mdz045,
author = {Abar, L and Sobiecki, JG and Cariolou, M and Nanu, N and Vieira, AR and Stevens, C and Aune, D and Greenwood, DC and Chan, DSM and Norat, T},
doi = {annonc/mdz045},
journal = {Ann Oncol},
pages = {528--541},
title = {Body size and obesity during adulthood, and risk of lympho-haematopoietic cancers: an update of the WCRF-AICR systematic review of published prospective studies.},
url = {http://dx.doi.org/10.1093/annonc/mdz045},
volume = {30},
year = {2019}
}

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TY  - JOUR
AB  - BACKGROUND: To summarise the evidence on the associations between body mass index (BMI) and BMI in early adulthood, height, waist circumference (WC) and waist-to-hip ratio (WHR), and risk of lympho-haematopoietic cancers. METHOD: We conducted a meta-analysis of prospective studies and identified relevant studies published up to December 2017 by searching PubMed. A random-effects model was used to calculate dose-response summary relative risks (RRs). RESULTS: Our findings showed BMI, and BMI in early adulthood (aged 18-21years) is associated with the risk of Hodgkin's and non-Hodgkin's lymphoma (HL and NHL), diffuse large beta-cell lymphoma (DLBCL), Leukaemia including acute and chronic myeloid lymphoma (AML and CML), and chronic lymphocytic leukaemia (CLL) and multiple myeloma (MM). The summary RR per 5kg/m2 increase in BMI were 1.12 [95% confidence interval (CI): 1.05-1.20] for HL, 1.05 (95% CI: 1.03-1.08) for NHL, 1.11 (95% CI: 1.05-1.16) for DLBCL, 1.06 (95% CI: 1.03-1.09) for ML, 1.09 (95% CI: 1.03-1.15) for leukaemia, 1.13 (95% CI: 1.04-1.24) for AML, 1.13 (95% CI: 1.05-1.22) for CML and 1.04 (95% CI: 1.00-1.09) for CLL, and were1.12 (95% CI: 1.05-1.19) for NHL, 1.22 (95% CI: 1.09-1.37) for DLBCL, and 1.19 (95% CI: 1.03-1.38) for FL for BMI in early adulthood analysis. Results on mortality showed a 15%, 16% and 17% increased risk of NHL, MM and leukaemia, respectively. Greater height increased the risk of NHL by 7%, DLBCL by 10%, FL by 9%, MM by 5% and Leukaemia by 7%. WHR was associated with increased risk of DLBCL by 12%. No association was found between higher WC and risk of MM. CONCLUSION: Our results revealed that general adiposity in adulthood and early adulthood, and greater height may increase the risk of almost all types of lympho-haematopoietic cancers and this adds to a growing body of evidence linking body fatness to several types of cancers.
AU  - Abar,L
AU  - Sobiecki,JG
AU  - Cariolou,M
AU  - Nanu,N
AU  - Vieira,AR
AU  - Stevens,C
AU  - Aune,D
AU  - Greenwood,DC
AU  - Chan,DSM
AU  - Norat,T
DO  - annonc/mdz045
EP  - 541
PY  - 2019///
SN  - 0923-7534
SP  - 528
TI  - Body size and obesity during adulthood, and risk of lympho-haematopoietic cancers: an update of the WCRF-AICR systematic review of published prospective studies.
T2  - Ann Oncol
UR  - http://dx.doi.org/10.1093/annonc/mdz045
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31987269
UR  - https://academic.oup.com/annonc/article/30/4/528/5308595
UR  - http://hdl.handle.net/10044/1/71436
VL  - 30
ER  -

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