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@article{Perez-Cornago:2020:10.1002/ijc.32233,
author = {Perez-Cornago, A and Huybrechts, I and Appleby, PN and Schmidt, JA and Crowe, FL and Overvad, K and Tjønneland, A and Kühn, T and Katzke, V and Trichopoulou, A and Karakatsani, A and Peppa, E and Grioni, S and Palli, D and Sacerdote, C and Tumino, R and Bueno-de-Mesquita, HB and Larrañaga, N and Sánchez, M-J and Quirós, JR and Ardanaz, E and Chirlaque, M-D and Agudo, A and Bjartell, A and Wallström, P and Chajes, V and Tsilidis, KK and Aune, D and Riboli, E and Travis, RC and Key, TJ},
doi = {10.1002/ijc.32233},
journal = {International Journal of Cancer},
pages = {44--57},
title = {Intake of individual fatty acids and risk of prostate cancer in the European prospective investigation into cancer and nutrition},
url = {http://dx.doi.org/10.1002/ijc.32233},
volume = {146},
year = {2020}
}

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TY  - JOUR
AB  - The associations of individual dietary fatty acids with prostate cancer risk have not been examined comprehensively. We examined the prospective association of individual dietary fatty acids with prostate cancer risk overall, by tumor subtypes, and prostate cancer death. 142,239 men from the European Prospective Investigation into Cancer and Nutrition who were free from cancer at recruitment were included. Dietary intakes of individual fatty acids were estimated using center-specific validated dietary questionnaires at baseline and calibrated with 24-hour recalls. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average follow-up of 13.9 years, 7,036 prostate cancer cases and 936 prostate cancer deaths were ascertained. Intakes of individual fatty acids were not related to overall prostate cancer risk. There was evidence of heterogeneity in the association of some short chain saturated fatty acids with prostate cancer risk by tumor stage (Pheterogeneity <0.015), with a positive association with risk of advanced stage disease for butyric acid (4:0; HR1SD =1.08; 95%CI=1.01-1.15; P-trend=0.026). There were no associations with fatal prostate cancer, with the exception of a slightly higher risk for those who consumed more eicosenoic acid (22:1n-9c; HR1SD =1.05; 1.00-1.11; P-trend=0.048) and eicosapentaenoic acid (20:5n-3c; HR1SD =1.07; 1.00-1.14; P-trend=0.045). There was no evidence that dietary intakes of individual fatty acids were associated with overall prostate cancer risk. However, a higher intake of butyric acid might be associated with a higher risk of advanced, whereas intakes of eicosenoic and eicosapentaenoic acids might be positively associated with fatal prostate cancer risk. This article is protected by copyright. All rights reserved.
AU  - Perez-Cornago,A
AU  - Huybrechts,I
AU  - Appleby,PN
AU  - Schmidt,JA
AU  - Crowe,FL
AU  - Overvad,K
AU  - Tjønneland,A
AU  - Kühn,T
AU  - Katzke,V
AU  - Trichopoulou,A
AU  - Karakatsani,A
AU  - Peppa,E
AU  - Grioni,S
AU  - Palli,D
AU  - Sacerdote,C
AU  - Tumino,R
AU  - Bueno-de-Mesquita,HB
AU  - Larrañaga,N
AU  - Sánchez,M-J
AU  - Quirós,JR
AU  - Ardanaz,E
AU  - Chirlaque,M-D
AU  - Agudo,A
AU  - Bjartell,A
AU  - Wallström,P
AU  - Chajes,V
AU  - Tsilidis,KK
AU  - Aune,D
AU  - Riboli,E
AU  - Travis,RC
AU  - Key,TJ
DO  - 10.1002/ijc.32233
EP  - 57
PY  - 2020///
SN  - 0020-7136
SP  - 44
TI  - Intake of individual fatty acids and risk of prostate cancer in the European prospective investigation into cancer and nutrition
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.32233
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30807653
UR  - http://hdl.handle.net/10044/1/67602
VL  - 146
ER  -

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