Imperial College London
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DrDagfinnAune

Faculty of Medicine, School of Public Health

Research Associate
 
 
 
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Contact

 

+44 (0)20 7594 8478d.aune

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rothwell:2022:10.1016/j.cgh.2020.11.045,
author = {Rothwell, JA and Murphy, N and Beevi, J and Kliemann, N and Jenab, M and Ferrari, P and Achaintre, D and Gicquiau, A and Vozar, B and Scalbert, A and Huybrechts, I and Freisling, H and Prehn, C and Adamski, J and Cross, AJ and Pala, VM and Boutron-Ruault, M-C and Dahm, CC and Overvad, K and Gram, IT and Sandanger, TM and Skeie, G and Jakszyn, P and Tsilidis, KK and Aleksandrova, K and Schulze, MB and Hughes, DJ and van, Guelpen B and Bodén, S and Sánchez, M-J and Schmidt, JA and Katzke, V and Kühn, T and Colorado-Yohar, S and Tumino, R and Bueno-de-Mesquita, B and Vineis, P and Masala, G and Panico, S and Eriksen, AK and Tjønneland, A and Aune, D and Weiderpass, E and Severi, G and Chajès, V and Gunter, MJ},
doi = {10.1016/j.cgh.2020.11.045},
journal = {Clinical Gastroenterology and Hepatology},
pages = {e1061--e1082},
title = {Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort},
url = {http://dx.doi.org/10.1016/j.cgh.2020.11.045},
volume = {20},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background & AimsColorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer cohort.MethodsScores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.ResultsHigher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants.ConclusionsMetabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
AU  - Rothwell,JA
AU  - Murphy,N
AU  - Beevi,J
AU  - Kliemann,N
AU  - Jenab,M
AU  - Ferrari,P
AU  - Achaintre,D
AU  - Gicquiau,A
AU  - Vozar,B
AU  - Scalbert,A
AU  - Huybrechts,I
AU  - Freisling,H
AU  - Prehn,C
AU  - Adamski,J
AU  - Cross,AJ
AU  - Pala,VM
AU  - Boutron-Ruault,M-C
AU  - Dahm,CC
AU  - Overvad,K
AU  - Gram,IT
AU  - Sandanger,TM
AU  - Skeie,G
AU  - Jakszyn,P
AU  - Tsilidis,KK
AU  - Aleksandrova,K
AU  - Schulze,MB
AU  - Hughes,DJ
AU  - van,Guelpen B
AU  - Bodén,S
AU  - Sánchez,M-J
AU  - Schmidt,JA
AU  - Katzke,V
AU  - Kühn,T
AU  - Colorado-Yohar,S
AU  - Tumino,R
AU  - Bueno-de-Mesquita,B
AU  - Vineis,P
AU  - Masala,G
AU  - Panico,S
AU  - Eriksen,AK
AU  - Tjønneland,A
AU  - Aune,D
AU  - Weiderpass,E
AU  - Severi,G
AU  - Chajès,V
AU  - Gunter,MJ
DO  - 10.1016/j.cgh.2020.11.045
EP  - 1082
PY  - 2022///
SN  - 1542-3565
SP  - 1061
TI  - Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort
T2  - Clinical Gastroenterology and Hepatology
UR  - http://dx.doi.org/10.1016/j.cgh.2020.11.045
UR  - http://hdl.handle.net/10044/1/85939
VL  - 20
ER  -
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