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@article{Aune:2021:2021/9376134,
author = {Aune, D and Huang, W and Nie, J and Wang, Y},
doi = {2021/9376134},
journal = {BioMed Research International},
pages = {1--10},
title = {Hypertension and all-cause and cause-specific mortality: An outcome-wide association study of 67 causes of death in the National Health Interview Survey.},
url = {http://dx.doi.org/10.1155/2021/9376134},
volume = {2021},
year = {2021}
}

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TY  - JOUR
AB  - Background. Few studies have assessed the association between hypertension and risk of detailed causes of death. We investigatedthe association between hypertension and all-cause mortality and 67 causes of death in a large cohort. Methods. Multivariable Coxregression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for self-reported hypertensionvs. no hypertension and mortality. Adults aged ≥18 years (n = 213798) were recruited in 1997-2004 and followed throughDecember 31, 2006. Results. During 5.81 years of follow-up, 11254 deaths occurred. Self-reported hypertension vs. nohypertension was associated with increased risk of all-cause mortality (HR = 1:25, 95% CI: 1.19-1.31) and mortality fromsepticemia (HR =1.66, 1.06-2.59), other infectious parasitic diseases (HR = 2:67, 1.09-6.51), diabetes mellitus (HR = 1:97, 1.45-2.67), circulatory disease (HR = 1:49, 1.37-1.61), hypertensive heart disease (HR = 3:23, 2.00-5.20), ischemic heart disease ðHR =1:35, 1.23-1.49), acute myocardial infarction (HR = 1:50, 1.27-1.77), other chronic ischemic heart diseases (HR = 1:35, 1.17-1.56), all other forms of heart disease (HR = 1:51, 1.21-1.89), primary hypertension and renal disease (HR = 3:11, 1.82-5.30),cerebrovascular disease (HR = 1:64, 1.37-1.97), other circulatory system diseases (HR = 1:71, 1.09-2.69), other chronic lowerrespiratory diseases (HR = 1:39, 1.12-1.73), other chronic liver disease (HR = 1:89, 1.06-3.37), renal failure (HR = 1:91, 1.33-2.74), motor vehicle accidents (HR = 1:60, 1.07-2.37), and all other diseases (HR =1.30, 1.10-1.54), but with lower risk of uterinecancer (HR = 0:37, 95% CI: 0.15-0.90) and Alzheimer’s disease (HR = 0:65, 95% CI: 0.47-0.92). Conclusion. Hypertension wasassociated with increased risk of all-cause mortality and 17 out of 67 causes of death, with most of these being circulatorydisease outcomes, however, some of the remaining associations are unlikely to be causal. Further studies ar
AU  - Aune,D
AU  - Huang,W
AU  - Nie,J
AU  - Wang,Y
DO  - 2021/9376134
EP  - 10
PY  - 2021///
SN  - 1110-7243
SP  - 1
TI  - Hypertension and all-cause and cause-specific mortality: An outcome-wide association study of 67 causes of death in the National Health Interview Survey.
T2  - BioMed Research International
UR  - http://dx.doi.org/10.1155/2021/9376134
UR  - https://www.hindawi.com/journals/bmri/2021/9376134/
UR  - http://hdl.handle.net/10044/1/90629
VL  - 2021
ER  -

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