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@article{Naghshi:2021:10.1136/bmj.n2213,
author = {Naghshi, S and Aune, D and Beyene, J and Mobarak, S and Asadi, M and Sadeghi, O},
doi = {10.1136/bmj.n2213},
journal = {BMJ: British Medical Journal},
pages = {n2213--n2213},
title = {Dietary intake and biomarkers of alpha linolenic acid and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of cohort studies},
url = {http://dx.doi.org/10.1136/bmj.n2213},
volume = {375},
year = {2021}
}

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TY  - JOUR
AB  - OBJECTIVE: To examine the associations between dietary intake and tissue biomarkers of alpha linolenic acid (ALA) and risk of mortality from all causes, cardiovascular disease (CVD), and cancer. DESIGN: Systematic review and meta-analysis of prospective cohort studies. DATA SOURCES: PubMed, Scopus, ISI Web of Science, and Google Scholar to 30 April 2021. STUDY SELECTION: Prospective cohort studies that reported the risk estimates for death from all causes, CVD, and cancer. DATA SYNTHESIS: Summary relative risks and 95% confidence intervals were calculated for the highest versus lowest categories of ALA intake using random effects and fixed effects models. Linear and non-linear dose-response analyses were conducted to assess the dose-response associations between ALA intake and mortality. RESULTS: 41 articles from prospective cohort studies were included in this systematic review and meta-analysis, totalling 1 197 564 participants. During follow-up ranging from two to 32 years, 198 113 deaths from all causes, 62 773 from CVD, and 65 954 from cancer were recorded. High intake of ALA compared with low intake was significantly associated with a lower risk of deaths from all causes (pooled relative risk 0.90, 95% confidence interval 0.83 to 0.97, I2=77.8%, 15 studies), CVD (0.92, 0.86 to 0.99, I2=48.2%, n=16), and coronary heart disease (CHD) (0.89, 0.81 to 0.97, I2=5.6%, n=9), and a slightly higher risk of cancer mortality (1.06, 1.02 to 1.11, I2=3.8%, n=10). In the dose-response analysis, a 1 g/day increase in ALA intake (equivalent to one tablespoon of canola oil or 0.5 ounces of walnut) was associated with a 5% lower risk of all cause (0.95, 0.91 to 0.99, I2=76.2%, n=12) and CVD mortality (0.95, 0.91 to 0.98, I2=30.7%, n=14). The pooled relative risks for the highest compared with lowest tissue levels of ALA indicated a significant inverse association with all cause mortality (0.95, 0.90 to 0.99, I2=8.2%, n=26). Also, based on the d
AU  - Naghshi,S
AU  - Aune,D
AU  - Beyene,J
AU  - Mobarak,S
AU  - Asadi,M
AU  - Sadeghi,O
DO  - 10.1136/bmj.n2213
EP  - 2213
PY  - 2021///
SN  - 0959-535X
SP  - 2213
TI  - Dietary intake and biomarkers of alpha linolenic acid and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of cohort studies
T2  - BMJ: British Medical Journal
UR  - http://dx.doi.org/10.1136/bmj.n2213
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34645650
UR  - http://hdl.handle.net/10044/1/96557
VL  - 375
ER  -

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