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@article{Kliemann:2022:10.1158/1055-9965.epi-22-0160,
author = {Kliemann, N and Ould, Ammar R and Biessy, C and Gicquiau, A and Katzke, V and Kaaks, R and Tjoenneland, A and Olsen, A and Sánchez, M-J and Crous-Bou, M and Pasanisi, F and Tin, Tin S and Perez-Cornago, A and Aune, D and Christakoudi, S and Heath, AK and Colorado-Yohar, SM and Grioni, S and Skeie, G and Sartor, H and Idahl, A and Rylander, C and M, May A and Weiderpass, E and Freisling, H and Playdon, MC and Rinaldi, S and Murphy, N and Huybrechts, I and Dossus, L and Gunter, MJ},
doi = {10.1158/1055-9965.epi-22-0160},
journal = {Cancer Epidemiology, Biomarkers and Prevention},
pages = {1359--1367},
title = {Metabolically-defined body size phenotypes and risk of endometrial cancer in the European prospective investigation into cancer and nutrition (EPIC)},
url = {http://dx.doi.org/10.1158/1055-9965.epi-22-0160},
volume = {31},
year = {2022}
}

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TY  - JOUR
AB  - Background: Obesity is a risk factor for endometrial cancer but whether metabolic dysfunction is associated with endometrial cancer independent of body size is not known. Methods: The association of metabolically-defined body size phenotypes with endometrial cancer risk was investigated in a nested case-control study (817 cases/ 817 controls) within the European Prospective Investigation into Cancer and Nutrition (EPIC). Concentrations of C-peptide were used to define metabolically healthy (MH; <1st tertile) and metabolically unhealthy (MU; >=1st tertile) status among the control participants. These metabolic health definitions were combined with normal weight (NW; Body Mass Index (BMI)<25kg/m2 or Waist Circumference (WC)<80cm or Waist-to-Hip Ratio (WHR)<0.8) and overweight (OW; BMI>=25kg/m2 or WC>=80cm or WHR>=0.8) status, generating four phenotype groups for each anthropometric measure: (1)MH/NW, (2)MH/OW (3)MU/NW and (4)MU/OW. Results: In a multivariable-adjusted conditional logistic regression model, compared with MH/NW individuals, endometrial cancer risk was higher among those classified as MU/NW (OR/WC=1.48; 95%CI 1.05-2.10 and OR/WHR=1.68; 95%CI 1.21-2.35) and MU/OW (OR/BMI=2.38, 95%CI 1.73-3.27; OR/WC=2.69, 95%CI 1.92-3.77 and OR/WHR=1.83, 95%CI 1.32-2.54). MH/OW individuals were also at increased endometrial cancer risk compared to MH/NW individuals (OR/WC=1.94, 95%CI 1.24-3.04). Conclusions: Women with metabolic dysfunction appear to have higher risk of endometrial cancer regardless of their body size. However, overweight status raises endometrial cancer risk even among women with lower insulin levels, suggesting that obesity-related pathways are relevant for the development of this cancer beyond insulin. Impact: Classifying women by metabolic health may be of greater utility in identifying those at higher risk for endometrial cancer than anthropometry per se.
AU  - Kliemann,N
AU  - Ould,Ammar R
AU  - Biessy,C
AU  - Gicquiau,A
AU  - Katzke,V
AU  - Kaaks,R
AU  - Tjoenneland,A
AU  - Olsen,A
AU  - Sánchez,M-J
AU  - Crous-Bou,M
AU  - Pasanisi,F
AU  - Tin,Tin S
AU  - Perez-Cornago,A
AU  - Aune,D
AU  - Christakoudi,S
AU  - Heath,AK
AU  - Colorado-Yohar,SM
AU  - Grioni,S
AU  - Skeie,G
AU  - Sartor,H
AU  - Idahl,A
AU  - Rylander,C
AU  - M,May A
AU  - Weiderpass,E
AU  - Freisling,H
AU  - Playdon,MC
AU  - Rinaldi,S
AU  - Murphy,N
AU  - Huybrechts,I
AU  - Dossus,L
AU  - Gunter,MJ
DO  - 10.1158/1055-9965.epi-22-0160
EP  - 1367
PY  - 2022///
SN  - 1055-9965
SP  - 1359
TI  - Metabolically-defined body size phenotypes and risk of endometrial cancer in the European prospective investigation into cancer and nutrition (EPIC)
T2  - Cancer Epidemiology, Biomarkers and Prevention
UR  - http://dx.doi.org/10.1158/1055-9965.epi-22-0160
UR  - https://aacrjournals.org/cebp/article/doi/10.1158/1055-9965.EPI-22-0160/694485/Metabolically-Defined-Body-Size-Phenotypes-and
UR  - http://hdl.handle.net/10044/1/96669
VL  - 31
ER  -

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