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@article{Yang:2022:jncics/pkac009,
author = {Yang, JJ and Yu, D and White, E and Lee, DH and Blot, W and Robien, K and Sinha, R and Park, Y and Takata, Y and Gao, Y-T and Smith-Byrne, K and Monninkhof, EM and Kaaks, R and Langhammer, A and Borch, KB and Al-Shaar, L and Lan, Q and Sorgjerd, EP and Zhang, X and Zhu, C and Chirlaque, MD and Severi, G and Overvad, K and Sacerdote, C and Aune, D and Johansson, M and Smith-Warner, SA and Zheng, W and Shu, X-O},
doi = {jncics/pkac009},
journal = {JNCI Cancer Spectrum},
title = {Prediagnosis leisure-time physical activity and lung cancer survival: a pooled analysis of 11 cohorts},
url = {http://dx.doi.org/10.1093/jncics/pkac009},
volume = {6},
year = {2022}
}

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TY  - JOUR
AB  - BackgroundLittle is known about the association between physical activity before cancer diagnosis and survival among lung cancer patients. In this pooled analysis of 11 prospective cohorts, we investigated associations of prediagnosis leisure-time physical activity (LTPA) with all-cause and lung cancer–specific mortality among incident lung cancer patients.MethodsUsing self-reported data on regular engagement in exercise and sports activities collected at study enrollment, we assessed metabolic equivalent hours (MET-h) of prediagnosis LTPA per week. According to the Physical Activity Guidelines for Americans, prediagnosis LTPA was classified into inactivity, less than 8.3 and at least 8.3 MET-h per week (the minimum recommended range). Cox regression was used to estimate hazard ratios (HRs) and 95% confidence interval (CIs) for all-cause and lung cancer–specific mortality after adjustment for major prognostic factors and lifetime smoking history.ResultsOf 20494 incident lung cancer patients, 16864 died, including 13596 deaths from lung cancer (overall 5-year relative survival rate = 20.9%, 95% CI = 20.3% to 21.5%). Compared with inactivity, prediagnosis LTPA of more than 8.3 MET-h per week was associated with a lower hazard of all-cause mortality (multivariable-adjusted HR = 0.93, 95% CI = 0.88 to 0.99), but not with lung cancer–specific mortality (multivariable-adjusted HR = 0.99, 95% CI = 0.95 to 1.04), among the overall population. Additive interaction was found by tumor stage (Pinteraction = .008 for all-cause mortality and .003 for lung cancer–specific mortality). When restricted to localized cancer, prediagnosis LTPA of at least 8.3 MET-h per week linked to 20% lower mortality: multivariable-adjusted HRs were 0.80 (95% CI = 0.67 to 0.97) for all-cause mortality and 0.80 (95% CI = 0.65 to 0.99) for lung cancer–specific mortality.ConclusionsRegular participation in LTPA that met or exceeded the minimum Physical Activity Guideline
AU  - Yang,JJ
AU  - Yu,D
AU  - White,E
AU  - Lee,DH
AU  - Blot,W
AU  - Robien,K
AU  - Sinha,R
AU  - Park,Y
AU  - Takata,Y
AU  - Gao,Y-T
AU  - Smith-Byrne,K
AU  - Monninkhof,EM
AU  - Kaaks,R
AU  - Langhammer,A
AU  - Borch,KB
AU  - Al-Shaar,L
AU  - Lan,Q
AU  - Sorgjerd,EP
AU  - Zhang,X
AU  - Zhu,C
AU  - Chirlaque,MD
AU  - Severi,G
AU  - Overvad,K
AU  - Sacerdote,C
AU  - Aune,D
AU  - Johansson,M
AU  - Smith-Warner,SA
AU  - Zheng,W
AU  - Shu,X-O
DO  - jncics/pkac009
PY  - 2022///
SN  - 2515-5091
TI  - Prediagnosis leisure-time physical activity and lung cancer survival: a pooled analysis of 11 cohorts
T2  - JNCI Cancer Spectrum
UR  - http://dx.doi.org/10.1093/jncics/pkac009
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000774206100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://academic.oup.com/jncics/article/6/2/pkac009/6528328
UR  - http://hdl.handle.net/10044/1/97188
VL  - 6
ER  -

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