Imperial College London
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DrDagfinnAune

Faculty of Medicine, School of Public Health

Research Associate
 
 
 
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Contact

 

+44 (0)20 7594 8478d.aune

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sæby:2023:10.1007/s00394-022-02942-8,
author = {Sæby, Dybvik J and Svendsen, M and Aune, D},
doi = {10.1007/s00394-022-02942-8},
journal = {European Journal of Nutrition},
pages = {51--69},
title = {Vegetarian and vegan diets and the risk of cardiovascular disease, ischemic heart disease and stroke: a systematic review and meta-analysis of prospective cohort studies},
url = {http://dx.doi.org/10.1007/s00394-022-02942-8},
volume = {62},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Purpose:Vegetarian diets have been associated with reduced risk of ischemic heart disease (IHD). However, results regarding cardiovascular disease (CVD) overall and stroke are less clear. We conducted a systematic review and meta-analysis of prospective cohort studies on CVD, IHD and stroke risk among vegetarians or vegans versus nonvegetarians to clarify these associations.Methods:PubMed and Ovid Embase databases were searched through August 12, 2021. Prospective cohort studies reporting adjusted relative risk (RR) estimates and 95% confidence intervals (CIs) for incidence or mortality from CVD, IHD and stroke, comparing vegetarians and vegans to nonvegetarians were included. Risk of bias (RoB) was assessed using ROBINS-I and the strength of evidence was assessed using World Cancer Research Fund (WCRF) criteria. Summary RRs (95% CIs) were estimated using a random effects model.Results:Thirteen cohort studies (844,175 participants, 115,392 CVD, 30,377 IHD, and 14,419 stroke cases) were included. The summary RR for vegetarians vs. nonvegetarians was 0.85 (95% CI: 0.79–0.92, I2 = 68%, n = 8) for CVD, 0.79 (95% CI: 0.71–0.88, I2 = 67%, n = 8) for IHD, 0.90 (95% CI: 0.77–1.05, I2 = 61%, n = 12) for total stroke, and for vegans vs. nonvegetarians was 0.82 (95% CI: 0.68–1.00, I2 = 0%, n = 6) for IHD. RoB was moderate (n = 8) to serious (n = 5). The associations between vegetarian diets and CVD and IHD were considered probably causal using WCRF criteria.Conclusions:Vegetarian diets are associated with reduced risk of CVD and IHD, but not stroke, but further studies are needed on stroke. These findings should be considered in dietary guidelines.
AU  - Sæby,Dybvik J
AU  - Svendsen,M
AU  - Aune,D
DO  - 10.1007/s00394-022-02942-8
EP  - 69
PY  - 2023///
SN  - 0044-264X
SP  - 51
TI  - Vegetarian and vegan diets and the risk of cardiovascular disease, ischemic heart disease and stroke: a systematic review and meta-analysis of prospective cohort studies
T2  - European Journal of Nutrition
UR  - http://dx.doi.org/10.1007/s00394-022-02942-8
UR  - http://hdl.handle.net/10044/1/99326
VL  - 62
ER  -
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