Imperial College London
Alternate

Professor Duncan Bassett

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology
 
 
 
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Contact

 

+44 (0)20 3313 4613d.bassett Website

 
 
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Location

 

10N6 Commomwealth BuildingHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Steinberg:2021:10.1038/s41467-021-21593-7,
author = {Steinberg, J and Southam, L and Roumeliotis, TI and Clark, MJ and Jayasuriya, RL and Swift, D and Shah, KM and Butterfield, NC and Brooks, RA and McCaskie, AW and Bassett, JHD and Williams, GR and Choudhary, JS and Wilkinson, JM and Zeggini, E},
doi = {10.1038/s41467-021-21593-7},
journal = {Nat Commun},
title = {A molecular quantitative trait locus map for osteoarthritis.},
url = {http://dx.doi.org/10.1038/s41467-021-21593-7},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Osteoarthritis causes pain and functional disability for over 500 million people worldwide. To develop disease-stratifying tools and modifying therapies, we need a better understanding of the molecular basis of the disease in relevant tissue and cell types. Here, we study primary cartilage and synovium from 115 patients with osteoarthritis to construct a deep molecular signature map of the disease. By integrating genetics with transcriptomics and proteomics, we discover molecular trait loci in each tissue type and omics level, identify likely effector genes for osteoarthritis-associated genetic signals and highlight high-value targets for drug development and repurposing. These findings provide insights into disease aetiopathology, and offer translational opportunities in response to the global clinical challenge of osteoarthritis.
AU  - Steinberg,J
AU  - Southam,L
AU  - Roumeliotis,TI
AU  - Clark,MJ
AU  - Jayasuriya,RL
AU  - Swift,D
AU  - Shah,KM
AU  - Butterfield,NC
AU  - Brooks,RA
AU  - McCaskie,AW
AU  - Bassett,JHD
AU  - Williams,GR
AU  - Choudhary,JS
AU  - Wilkinson,JM
AU  - Zeggini,E
DO  - 10.1038/s41467-021-21593-7
PY  - 2021///
TI  - A molecular quantitative trait locus map for osteoarthritis.
T2  - Nat Commun
UR  - http://dx.doi.org/10.1038/s41467-021-21593-7
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33637762
UR  - http://hdl.handle.net/10044/1/87750
VL  - 12
ER  -
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