Publications

BibTex format

@article{Freudenthal:2016:10.1530/JOE-16-0258,
author = {Freudenthal, B and Logan, J and Sanger, Institute Mouse Pipelines2 and Croucher, PI and Williams, GR and Bassett, JHD},
doi = {10.1530/JOE-16-0258},
journal = {Journal of Endocrinology},
pages = {R31--R46},
title = {Rapid phenotyping of knockout mice to identify genetic determinants of bone strength},
url = {http://dx.doi.org/10.1530/JOE-16-0258},
volume = {231},
year = {2016}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The genetic determinants of osteoporosis remain poorly understood, and there is a large unmet need for new treatments in our ageing society. Thus, new approaches for gene discovery in skeletal disease are required to complement the current genome-wide association studies in human populations. The International Knockout Mouse Consortium (IKMC) and the International Mouse Phenotyping Consortium (IMPC) provide such an opportunity. The IKMC generates knockout mice representing each of the known protein-coding genes in C57BL/6 mice and, as part of the IMPC initiative, the Origins of Bone and Cartilage Disease project identifies mutants with significant outlier skeletal phenotypes. This initiative will add value to data from large human cohorts and provide a new understanding of bone and cartilage pathophysiology, ultimately leading to the identification of novel drug targets for the treatment of skeletal disease.
AU  - Freudenthal,B
AU  - Logan,J
AU  - Sanger,Institute Mouse Pipelines2
AU  - Croucher,PI
AU  - Williams,GR
AU  - Bassett,JHD
DO  - 10.1530/JOE-16-0258
EP  - 46
PY  - 2016///
SN  - 1479-6805
SP  - 31
TI  - Rapid phenotyping of knockout mice to identify genetic determinants of bone strength
T2  - Journal of Endocrinology
UR  - http://dx.doi.org/10.1530/JOE-16-0258
UR  - http://hdl.handle.net/10044/1/39207
VL  - 231
ER  -

Download

Professor Duncan Bassett

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)