Publications
255 results found
Bell D, Jackson M, MacRae C, et al., 1987, Neutrophil elastase a marker of neutrophil activation in acute myocardial-infarction, Clinical Science, Vol: 72, Pages: P87-P87, ISSN: 0143-5221
Bell D, Jackson M, Millar AM, et al., 1987, The acute inflammatory response to myocardial infarction: imaging with indium-111 labelled autologous neutrophils, British Heart Journal, Vol: 57, Pages: 23-27, ISSN: 0007-0769
The uptake of indium-111 labelled neutrophils was examined in 30 patients with acute myocardial infarction by planar imaging and single photon emission computed tomography. The time from venepuncture to reinjection of the autologous labelled neutrophils was less than 2.5 hours and imaging was carried out 24 hours later. Twenty three patients had a positive uptake of neutrophils in the myocardium and imaging was improved by single photon emission computed tomography. There was a significant difference between the intervals from the onset of chest pain to injection of labelled neutrophils between patients with positive and negative images; early reinjection was more likely to produce a positive image. Indeed, all nine patients reinjected within 18 hours of the onset of symptoms had positive images. The results suggest that the stimulus for activation and migration of neutrophils is transient; this is an important factor if neutrophil release products play a role in cell damage after coronary occlusion.
Bell D, Jackson M, Connaughton JJ, 1986, Indium-111 neutrophil imaging in ischemic colitis, J Nucl Med, Vol: 27, Pages: 1782-1783, ISSN: 0161-5505
Bell D, Collier AD, Jackson M, et al., 1986, Altered vascular compliance and capillary-permeability in type-1 (insulin-dependent) diabetes-mellitus, Diabetologia, Vol: 29, Pages: A516-A516, ISSN: 0012-186X
Bell D, Nicoll JJ, Connell M, et al., 1986, Imaging the acute inflammatory response in patients with acute myocardial-infarction using In-111 labeled autologous neutrophils, Scottish Medical Journal, Vol: 31, Pages: 215-215, ISSN: 0036-9330
Bell D, Millar AM, McGillivray M, et al., 1986, The preparation and in vivo behaviour of 111In-oxine labelled neutrophils separated from whole blood using mono-poly resolving medium, Nucl Med Commun, Vol: 7, Pages: 447-453, ISSN: 0143-3636
using a single step separation procedure, we have developed a method for labelling human neutrophils with 111In-oxine. This method allows a rapid separation of neutrophils from whole blood, with negligible mononuclear or red cell contamination. Preliminary studies using 111In-labelled neutrophils show minimal lung retention and early accumulation in the spleen consistent with viable cells. In addition, focal accumulation of 111In has been imaged in patients with localized inflammation or sepsis.
Bell D, Connaughton J, Muir AL, 1986, Salbutamol improves gravitational distribution of ventilation in patients with chronic obstructive lung-disease, Clinical Science, Vol: 71, Pages: P63-P63, ISSN: 0143-5221
Matthews DM, Wathen CG, Bell D, et al., 1986, The effect of captopril on blood-pressure and glucose-tolerance in hypertensive non-insulin-dependent diabetics, Postgraduate Medical Journal, Vol: 62, Pages: 73-75, ISSN: 0032-5473
Bell D, Mackay IG, Pentland B, 1985, Hypereosinophilic syndrome presenting as peripheral neuropathy, Postgrad Med J, Vol: 61, Pages: 429-432, ISSN: 0032-5473
An unusual case of hypereosinophilic syndrome is described which presented with peripheral neuropathy with no evidence of cardiac involvement. The response to steroid therapy is documented and the literature on peripheral neuropathy in hypereosinophilic syndrome is reviewed.
Muir AL, Adie CJ, Kirby TP, et al., 1985, Regional tidal volume assessed by gated lung imaging, Nucl Med Commun, Vol: 6, Pages: 127-139, ISSN: 0143-3636
We have measured regional lung tidal volumes and functional residual capacities by accumulating and framing iso-volumic images while the patient rebreathes 127Xe. As the lung changes shape during ventilation corrections for changes in geometry were obtained by simultaneous collection of 99Tcm counts from the gated perfusion scan. Regions of interest were made to vary throughout the respiratory cycle so that a region had always the same value of 99Tcm counts. From the corrected 127Xe counts regional tidal volumes (TVr) and functional residual capacities (FRCr) were derived. In patients with established chronic bronchitis and emphysema FRCr were greater and the ratio TVr/FRCr decreased compared with patients with relatively normal static and dynamic lung volumes. Preliminary studies suggest that this ratio was a better discriminator between normal and abnormal regional function than estimates of regional xenon washout. Studies with xenon-133 have contributed to our understanding of the physiology of ventilation but have contributed somewhat less to routine clinical practice. This results in part from the unsatisfactory physical properties of xenon-133. Its relatively low gamma ray energy of 80 keV results in significant self-absorption losses and the activity which may be administered is limited by the radiation dose from the associated beta particles so that relatively poor counting statistics are obtained. With inhaled technetium-99m (99Tcm) microspheres imaging conditions are greatly improved but the distribution of these particles may not equate with the distribution of ventilation particularly if wet particles are used. Moreover, simultaneous microsphere perfusion scans with technetium-99m as a label are impossible. Krypton-81m gas has a suitable energy but the short half-life of the rubidium-81m generator (4.7 h) makes supply difficult and the ultrashort half-life of the krypton-81m gas (13 s) leads to problems in calculating the indices of ventilation. Xenon-12
Warren PM, Jeffrey AJ, Haslett C, et al., 1985, Guidelines for treatment of acute respiratory-failure in chronic-bronchitis and emphysema - comparison of admissions between 1970-76 and 1979-82, Scottish Medical Journal, Vol: 30, Pages: 196-196, ISSN: 0036-9330
Muir AL, Hannan WJ, Bell D, et al., 1984, Gated ventilation scanning - a new approach to regional pulmonary-function, Thorax, Vol: 39, Pages: 221-221, ISSN: 0040-6376
Bell D, MacDonald MK, Thomson D, 1983, Localization of receptor for active 3rd component of complement (C3B) in human glomerulus and its alteration in glomerulonephritis, Journal of Pathology, Vol: 141, Pages: 535-535, ISSN: 0022-3417
Cumming AD, Simpson G, Bell D, et al., 1982, Acute aluminium intoxication in patients on continuous ambulatory peritoneal dialysis, Lancet, Vol: 1, Pages: 103-104, ISSN: 0140-6736
Bell D, Paterson R, MacLeod D, Standardised early warning scoring system - In response, CLINICAL MEDICINE, Vol: 6, Pages: 423-424, ISSN: 1470-2118
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