Imperial College London
Alternate

Emeritus ProfessorDerekBell

Faculty of Medicine, School of Public Health

Emeritus Professor in Acute Medicine
 
 
 
//

Contact

 

+44 (0)7886 725 212d.bell

 
 
//

Assistant

 

Miss Heather Barnes +44 (0)20 3315 8144

 
//

Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Cafferkey:2023:10.1177/17511437221103692,
author = {Cafferkey, J and Ferguson, A and Grahamslaw, J and Oatey, K and Norrie, J and Lone, N and Walsh, T and Horner, D and Appelboam, A and Hall, P and Skipworth, R and Bell, D and Rooney, K and Shankar-Hari, M and Corfield, A and Gray, A},
doi = {10.1177/17511437221103692},
journal = {Journal of the Intensive Care Society},
pages = {78--84},
title = {Albumin versus balanced crystalloid for resuscitation in the treatment of sepsis: a protocol for a randomised controlled feasibility study, "ABC-Sepsis"},
url = {http://dx.doi.org/10.1177/17511437221103692},
volume = {24},
year = {2023}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundPatients presenting with suspected sepsis to secondary care often require fluid resuscitation to correct hypovolaemia and/or septic shock. Existing evidence signals, but does not demonstrate, a benefit for regimes including albumin over balanced crystalloid alone. However, interventions may be started too late, missing a critical resuscitation window.MethodsABC Sepsis is a currently recruiting randomised controlled feasibility trial comparing 5% human albumin solution (HAS) with balanced crystalloid for fluid resuscitation in patients with suspected sepsis. This multicentre trial is recruiting adult patients within 12 hours of presentation to secondary care with suspected community acquired sepsis, with a National Early Warning Score ≥5, who require intravenous fluid resuscitation. Participants are randomised to 5% HAS or balanced crystalloid as the sole resuscitation fluid for the first 6 hours.ObjectivesPrimary objectives are feasibility of recruitment to the study and 30-day mortality between groups. Secondary objectives include in-hospital and 90-day mortality, adherence to trial protocol, quality of life measurement and secondary care costs.DiscussionThis trial aims to determine the feasibility of conducting a trial to address the current uncertainty around optimal fluid resuscitation of patients with suspected sepsis. Understanding the feasibility of delivering a definitive study will be dependent on how the study team are able to negotiate clinician choice, Emergency Department pressures and participant acceptability, as well as whether any clinical signal of benefit is detected.
AU  - Cafferkey,J
AU  - Ferguson,A
AU  - Grahamslaw,J
AU  - Oatey,K
AU  - Norrie,J
AU  - Lone,N
AU  - Walsh,T
AU  - Horner,D
AU  - Appelboam,A
AU  - Hall,P
AU  - Skipworth,R
AU  - Bell,D
AU  - Rooney,K
AU  - Shankar-Hari,M
AU  - Corfield,A
AU  - Gray,A
DO  - 10.1177/17511437221103692
EP  - 84
PY  - 2023///
SN  - 1751-1437
SP  - 78
TI  - Albumin versus balanced crystalloid for resuscitation in the treatment of sepsis: a protocol for a randomised controlled feasibility study, "ABC-Sepsis"
T2  - Journal of the Intensive Care Society
UR  - http://dx.doi.org/10.1177/17511437221103692
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000935994200010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://journals.sagepub.com/doi/10.1177/17511437221103692
VL  - 24
ER  -
Download