Imperial College London

Dr. Doryen Bubeck

Faculty of Natural SciencesDepartment of Life Sciences

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2989d.bubeck Website

 
 
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Location

 

506Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Summary

Complement membrane attack complexDoryen Bubeck received her PhD in Biophysics from Harvard University in 2005 where she used cryo-electron microscopy (cryo-EM) to investigate the cell entry mechanism of poliovirus.  As an EMBO postdoctoral fellow and Cancer Research Institute Fellow at the University of Oxford, she continued to explore the structures of membrane proteins, focusing on the complement immune pathway. Over 50 years since the complement membrane attack complex was visualized, a recent highlight from the lab reports the first 3D structure of the complete pore.  These results provide a framework for understanding the complex protein associations underlying activation of this innate immune effector and opens new directions of research investigating the lipid environment’s impact on MAC function. Doryen Bubeck is a senior lecturer in Structural Biology  within the Department of Life Sciences and holds a Satellite Group Leader position at the Francis Crick Institute. Her current research adopts a structural to investigate the role of membrane proteins in host-pathogen interactions. She aims to investigate how membrane attack complex (MAC) pore formation is controlled, a process important for fighting infections and preventing complement-mediated tissue damage.


Selected Publications

Journal Articles

Menny A, Serna M, Boyd CM, et al., 2018, CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers, Nature Communications, Vol:9, ISSN:2041-1723

Boyd CM, Bubeck D, 2018, Advances in cryoEM and its impact on beta-pore forming proteins, Current Opinion in Structural Biology, Vol:52, ISSN:0959-440X, Pages:41-49

Boyd CM, Parsons ES, Smith RAG, et al., 2016, Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation, Scientific Reports, Vol:6, ISSN:2045-2322

Serna M, Giles JL, Morgan BP, et al., 2016, Structural basis of complement membrane attack complex formation, Nature Communications, Vol:7, ISSN:2041-1723

Johnson S, Brooks NJ, Smith RAG, et al., 2013, Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59, Cell Reports, Vol:3, ISSN:2211-1247, Pages:1369-1377

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