Imperial College London
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Dr. Doryen Bubeck

Faculty of Natural Sciences, Department of Life Sciences

Professor in Structural Immunology
 
 
 
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Contact

 

+44 (0)20 7594 2989d.bubeck Website

 
 
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Location

 

506Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Boyd:2018:10.1016/j.sbi.2018.07.010,
author = {Boyd, CM and Bubeck, DA},
doi = {10.1016/j.sbi.2018.07.010},
journal = {Current Opinion in Structural Biology},
pages = {41--49},
title = {Advances in cryoEM and its impact on beta-pore forming proteins},
url = {http://dx.doi.org/10.1016/j.sbi.2018.07.010},
volume = {52},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Deployed by both hosts and pathogens, β-pore-forming proteins (β-PFPs) rupture membranes and lyse target cells. Soluble protein monomers oligomerize on the lipid bilayer where they undergo dramatic structural rearrangements, resulting in a transmembrane β-barrel pore. Advances in electron cryo-microscopy (cryoEM) sample preparation, image detection, and computational algorithms have led to a number of recent structures that reveal a molecular mechanism of pore formation in atomic detail.
AU  - Boyd,CM
AU  - Bubeck,DA
DO  - 10.1016/j.sbi.2018.07.010
EP  - 49
PY  - 2018///
SN  - 0959-440X
SP  - 41
TI  - Advances in cryoEM and its impact on beta-pore forming proteins
T2  - Current Opinion in Structural Biology
UR  - http://dx.doi.org/10.1016/j.sbi.2018.07.010
UR  - http://hdl.handle.net/10044/1/62958
VL  - 52
ER  -
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