17 results found
Chan DSM, Abar L, Cariolou M, et al., 2019, World Cancer Research Fund International: Continuous Update Project-systematic literature review and meta-analysis of observational cohort studies on physical activity, sedentary behavior, adiposity, and weight change and breast cancer risk, CANCER CAUSES & CONTROL, Vol: 30, Pages: 1183-1200, ISSN: 0957-5243
Chan DSM, Bandera EV, Greenwood DC, et al., 2015, Circulating C-Reactive Protein and Breast Cancer Risk-Systematic Literature Review and Meta-analysis of Prospective Cohort Studies, Cancer Epidemiology, Biomarkers and Prevention, Vol: 24, Pages: 1439-1449, ISSN: 1055-9965
We conducted a systematic literature review to explore the association between circulating C-reactive protein (CRP), a low-grade inflammation biomarker, and breast cancer risk. Relevant prospective studies in women were identified in PubMed and Web of Science until February 2015. Random-effects dose–response meta-analysis was conducted, overall and in postmenopausal women. Twelve out of 15 studies identified were included in the meta-analysis on any breast cancers (3,522 cases; 69,610 women) and nine on postmenopausal breast cancer (2,516 cases; 36,847 women). For each doubling of CRP concentration, a 7% [95% confidence interval (CI), 2%–12%] and 6% (95% CI, 1%–11%) increased risk was observed (I2 = 47% and 32%; Pheterogeneity = 0.04 and 0.17), respectively. The association was linear over most of the range of CRP concentrations. Positive associations remained in the studies that examined the exclusion of early years of follow-up. Associations were attenuated in studies adjusted for lifestyle factors, which partly explained the significant heterogeneity between studies in the overall analysis. On average, the associations in studies adjusted or not adjusted for body mass index were similar. Low-grade inflammation may have a role in breast cancer development. Additional prospective studies are needed to better understand confounding and effect modification from lifestyle factors.
Chan DSM, Norat T, 2015, Obesity and Breast Cancer: Not Only a Risk Factor of the Disease, CURRENT TREATMENT OPTIONS IN ONCOLOGY, Vol: 16, ISSN: 1527-2729
Chan DSM, Vieira AR, Aune D, et al., 2014, Body mass index and survival in women with breast cancer-systematic literature review and meta-analysis of 82 follow-up studies, ANNALS OF ONCOLOGY, Vol: 25, Pages: 1901-1914, ISSN: 0923-7534
Aune D, Chan DSM, Vieira AR, et al., 2012, Dietary fructose, carbohydrates, glycemic indices and pancreatic cancer risk: a systematic review and meta-analysis of cohort studies, ANNALS OF ONCOLOGY, Vol: 23, Pages: 2536-2546, ISSN: 0923-7534
Aune D, Vieira AR, Chan DSM, et al., 2012, Height and pancreatic cancer risk: a systematic review and meta-analysis of cohort studies, CANCER CAUSES & CONTROL, Vol: 23, Pages: 1213-1222, ISSN: 0957-5243
Aune D, Chan DSM, Vieira AR, et al., 2012, Dietary compared with blood concentrations of carotenoids and breast cancer risk: a systematic review and meta-analysis of prospective studies, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 96, Pages: 356-373, ISSN: 0002-9165
Aune D, Chan DSM, Vieira AR, et al., 2012, Fruits, vegetables and breast cancer risk: a systematic review and meta-analysis of prospective studies, BREAST CANCER RESEARCH AND TREATMENT, Vol: 134, Pages: 479-493, ISSN: 0167-6806
Romaguera D, Vergnaud A-C, Peeters PH, et al., 2012, Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 96, Pages: 150-163, ISSN: 0002-9165
Aune D, Chan DSM, Greenwood DC, et al., 2012, Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies, ANNALS OF ONCOLOGY, Vol: 23, Pages: 1394-1402, ISSN: 0923-7534
Aune D, Greenwood DC, Chan DSM, et al., 2012, Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies, ANNALS OF ONCOLOGY, Vol: 23, Pages: 843-852, ISSN: 0923-7534
Aune D, Chan DSM, Lau R, et al., 2012, Carbohydrates, glycemic index, glycemic load, and colorectal cancer risk: a systematic review and meta-analysis of cohort studies, CANCER CAUSES & CONTROL, Vol: 23, Pages: 521-535, ISSN: 0957-5243
Aune D, Lau R, Chan DSM, et al., 2012, Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort studies, ANNALS OF ONCOLOGY, Vol: 23, Pages: 37-45, ISSN: 0923-7534
Aune D, Chan DSM, Lau R, et al., 2011, Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies, BMJ-BRITISH MEDICAL JOURNAL, Vol: 343, ISSN: 1756-1833
Aune D, Lau R, Chan DSM, et al., 2011, Nonlinear Reduction in Risk for Colorectal Cancer by Fruit and Vegetable Intake Based on Meta-analysis of Prospective Studies, GASTROENTEROLOGY, Vol: 141, Pages: 106-118, ISSN: 0016-5085
Chan DSM, Lau R, Aune D, et al., 2011, Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies, PLoS ONE, Vol: 6, Pages: 1-11, ISSN: 1932-6203
BackgroundThe evidence that red and processed meat influences colorectal carcinogenesis was judged convincing in the 2007 World Cancer Research Fund/American Institute of Cancer Research report. Since then, ten prospective studies have published new results. Here we update the evidence from prospective studies and explore whether there is a non-linear association of red and processed meats with colorectal cancer risk.Methods and FindingsRelevant prospective studies were identified in PubMed until March 2011. For each study, relative risks and 95% confidence intervals (CI) were extracted and pooled with a random-effects model, weighting for the inverse of the variance, in highest versus lowest intake comparison, and dose-response meta-analyses. Red and processed meats intake was associated with increased colorectal cancer risk. The summary relative risk (RR) of colorectal cancer for the highest versus the lowest intake was 1.22 (95% CI = 1.11−1.34) and the RR for every 100 g/day increase was 1.14 (95% CI = 1.04−1.24). Non-linear dose-response meta-analyses revealed that colorectal cancer risk increases approximately linearly with increasing intake of red and processed meats up to approximately 140 g/day, where the curve approaches its plateau. The associations were similar for colon and rectal cancer risk. When analyzed separately, colorectal cancer risk was related to intake of fresh red meat (RR for 100 g/day increase = 1.17, 95% CI = 1.05−1.31) and processed meat (RR for 50 g/day increase = 1.18, 95% CI = 1.10−1.28). Similar results were observed for colon cancer, but for rectal cancer, no significant associations were observed.ConclusionsHigh intake of red and processed meat is associated with significant increased risk of colorectal, colon and rectal cancers. The overall evidence of prospective studies supports limiting red and processed meat consumption as one of the dietary recommendations for the prevention of colorectal cancer.
Touvier M, Chan DSM, Lau R, et al., 2011, Meta-Analyses of Vitamin D Intake, 25-Hydroxyvitamin D Status, Vitamin D Receptor Polymorphisms, and Colorectal Cancer Risk, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 20, Pages: 1003-1016, ISSN: 1055-9965
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