Imperial College London
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Dr Doris SM Chan

Faculty of Medicine, School of Public Health

Research Fellow in Nutrition
 
 
 
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Contact

 

+44 (0)20 7594 8590d.chan

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chan:2019:10.1007/s10552-019-01223-w,
author = {Chan, DSM and Abar, L and Cariolou, M and Nanu, N and Greenwood, DC and Bandera, EV and McTiernan, A and Norat, T},
doi = {10.1007/s10552-019-01223-w},
journal = {Cancer Causes and Control},
pages = {1183--1200},
title = {World Cancer Research Fund International: Continuous Update Project-systematic literature review and meta-analysis of observational cohort studies on physical activity, sedentary behavior, adiposity, and weight change and breast cancer risk},
url = {http://dx.doi.org/10.1007/s10552-019-01223-w},
volume = {30},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PurposeThe purpose of the present study was to systematically review the complex associations between energy balance-related factors and breast cancer risk, for which previous evidence has suggested different associations in the life course of women and by hormone receptor (HR) status of the tumor.MethodsRelevant publications on adulthood physical activity, sedentary behavior, body mass index (BMI), waist and hip circumferences, waist-to-hip ratio, and weight change and pre- and postmenopausal breast cancer risk were identified in PubMed up to 30 April 2017. Random-effects meta-analyses were conducted to summarize the relative risks across studies.ResultsOne hundred and twenty-six observational cohort studies comprising over 22,900 premenopausal and 103,000 postmenopausal breast cancer cases were meta-analyzed. Higher physical activity was inversely associated with both pre- and postmenopausal breast cancers, whereas increased sitting time was positively associated with postmenopausal breast cancer. Although higher early adult BMI (ages 18–30 years) was inversely associated with pre- and postmenopausal breast cancers, adult weight gain and greater body adiposity increased breast cancer risk in postmenopausal women, and the increased risk was evident for HR+ but not HR− breast cancers, and among never but not current users of postmenopausal hormones. The evidence was less consistent in premenopausal women. There were no associations with adult weight gain, inverse associations with adult BMI (study baseline) and hip circumference, and non-significant associations with waist circumference and waist-to-hip ratio that were reverted to positive associations on average in studies accounting for BMI. No significant associations were observed for HR-defined premenopausal breast cancers.ConclusionBetter understanding on the impact of these factors on pre- and postmenopausal breast cancers and their subtypes along the life course is needed.
AU  - Chan,DSM
AU  - Abar,L
AU  - Cariolou,M
AU  - Nanu,N
AU  - Greenwood,DC
AU  - Bandera,EV
AU  - McTiernan,A
AU  - Norat,T
DO  - 10.1007/s10552-019-01223-w
EP  - 1200
PY  - 2019///
SN  - 0957-5243
SP  - 1183
TI  - World Cancer Research Fund International: Continuous Update Project-systematic literature review and meta-analysis of observational cohort studies on physical activity, sedentary behavior, adiposity, and weight change and breast cancer risk
T2  - Cancer Causes and Control
UR  - http://dx.doi.org/10.1007/s10552-019-01223-w
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000503223300003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007/s10552-019-01223-w
UR  - http://hdl.handle.net/10044/1/100407
VL  - 30
ER  -
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