Imperial College London
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Dr Doris SM Chan

Faculty of Medicine, School of Public Health

Research Fellow in Nutrition
 
 
 
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Contact

 

+44 (0)20 7594 8590d.chan

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vingeliene:2016:10.1007/s10552-016-0755-0,
author = {Vingeliene, S and Chan, DS and Aune, D and Vieira, AR and Polemiti, E and Stevens, C and Abar, L and Rosenblatt, DN and Greenwood, DC and Norat, T},
doi = {10.1007/s10552-016-0755-0},
journal = {Cancer Causes & Control},
pages = {837--851},
title = {An update of the WCRF/AICR systematic literature review on esophageal and gastric cancers and citrus fruits intake.},
url = {http://dx.doi.org/10.1007/s10552-016-0755-0},
volume = {27},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PURPOSE: The 2007 World Cancer Research Fund/American Institute for Cancer Research expert report concluded that foods containing vitamin C probably protect against esophageal cancer and fruits probably protect against gastric cancer. Most of the previous evidence was from case-control studies, which may be affected by recall and selection biases. More recently, several cohort studies have examined these associations. We conducted a systematic literature review of prospective studies on citrus fruits intake and risk of esophageal and gastric cancers. METHODS: PubMed was searched for studies published until 1 March 2016. We calculated summary relative risks and 95 % confidence intervals (95 % CI) using random-effects models. RESULTS: With each 100 g/day increase of citrus fruits intake, a marginally significant decreased risk of esophageal cancer was observed (summary RR 0.86, 95 % CI 0.74-1.00, 1,057 cases, six studies). The associations were similar for squamous cell carcinoma (RR 0.87, 95 % CI 0.69-1.08, three studies) and esophageal adenocarcinoma (RR 0.93, 95 % CI 0.78-1.11, three studies). For gastric cancer, the nonsignificant inverse association was observed for gastric cardia cancer (RR 0.75, 95 % CI 0.55-1.01, three studies), but not for gastric non-cardia cancer (RR 1.02, 95 % CI 0.90-1.16, four studies). Consistent summary inverse associations were observed when comparing the highest with lowest intake, with statistically significant associations for esophageal (RR 0.77, 95 % CI 0.64-0.91, seven studies) and gastric cardia cancers (RR 0.62, 95 % CI 0.39-0.99, three studies). CONCLUSIONS: Citrus fruits may decrease the risk of esophageal and gastric cardia cancers, but further studies are needed.
AU  - Vingeliene,S
AU  - Chan,DS
AU  - Aune,D
AU  - Vieira,AR
AU  - Polemiti,E
AU  - Stevens,C
AU  - Abar,L
AU  - Rosenblatt,DN
AU  - Greenwood,DC
AU  - Norat,T
DO  - 10.1007/s10552-016-0755-0
EP  - 851
PY  - 2016///
SN  - 1573-7225
SP  - 837
TI  - An update of the WCRF/AICR systematic literature review on esophageal and gastric cancers and citrus fruits intake.
T2  - Cancer Causes & Control
UR  - http://dx.doi.org/10.1007/s10552-016-0755-0
UR  - http://hdl.handle.net/10044/1/34452
VL  - 27
ER  -
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