Imperial College London
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Dr Doris SM Chan

Faculty of Medicine, School of Public Health

Research Fellow in Nutrition
 
 
 
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Contact

 

+44 (0)20 7594 8590d.chan

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Schlesinger:2017:annonc/mdx080,
author = {Schlesinger, S and Aleksandrova, K and Abar, L and Vieria, AR and Vingeliene, S and Polemiti, E and Stevens, CA and Greenwood, DC and Chan, DS and Aune, D and Norat, T},
doi = {annonc/mdx080},
journal = {Annals of Oncology},
title = {Adult weight gain and colorectal adenomas - a systematic review and meta-analysis.},
url = {http://dx.doi.org/10.1093/annonc/mdx080},
volume = {28},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Colorectal adenomas are known as precursors for the majority of colorectal carcinomas. While weight gain during adulthood has been identified as a risk factor for colorectal cancer, the association is less clear for colorectal adenomas. We conducted a systematic review and meta-analysis to quantify the evidence on this association. Methods: : We searched MEDLINE up to September 2016 to identify observational (prospective, cross-sectional and retrospective) studies on weight gain during adulthood and colorectal adenoma occurrence and recurrence. We conducted meta-analysis on high weight gain versus stable weight, linear and non-linear dose-response meta-analyses to analyze the association. Summary odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using a random effects model. Results: For colorectal adenoma occurrence, the summary OR was 1.39 (95% CI: 1.17-1.65; I 2 :43%, N =9 studies, cases=5,507) comparing high (midpoint: 17.4 kg) versus stable weight gain during adulthood and with each 5 kg weight gain the odds increased by 7% (2%-11%; I 2 :65%, N =7 studies). Although there was indication of non-linearity ( Pnon-linearity <0.001) there was an increased odds of colorectal adenoma throughout the whole range of weight gain. Three studies were identified investigating the association between weight gain and colorectal adenoma recurrence and data were limited to draw firm conclusions. Conclusions: Even a small amount of adult weight gain was related to a higher odds of colorectal adenoma occurrence. Our findings add to the benefits of weight control in adulthood regarding colorectal adenomas occurrence, which might be relevant for early prevention of colorectal cancer.
AU  - Schlesinger,S
AU  - Aleksandrova,K
AU  - Abar,L
AU  - Vieria,AR
AU  - Vingeliene,S
AU  - Polemiti,E
AU  - Stevens,CA
AU  - Greenwood,DC
AU  - Chan,DS
AU  - Aune,D
AU  - Norat,T
DO  - annonc/mdx080
PY  - 2017///
SN  - 1569-8041
TI  - Adult weight gain and colorectal adenomas - a systematic review and meta-analysis.
T2  - Annals of Oncology
UR  - http://dx.doi.org/10.1093/annonc/mdx080
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28327995
UR  - http://hdl.handle.net/10044/1/45886
VL  - 28
ER  -
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