Imperial College London
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DrDavidDajnak

Faculty of Medicine, School of Public Health

Deputy Head of ERG Modelling Group
 
 
 
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d.dajnak

 
 
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Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Walton:2016:10.1016/j.envint.2016.08.021,
author = {Walton, RT and Mudway, IS and Dundas, I and Marlin, N and Koh, LC and Aitlhadj, L and Vulliamy, T and Jamaludin, JB and Wood, HE and Barratt, BM and Beevers, S and Dajnak, D and Sheikh, A and Kelly, FJ and Griffiths, CJ and Grigg, J},
doi = {10.1016/j.envint.2016.08.021},
journal = {Environ Int},
pages = {41--47},
title = {Air pollution, ethnicity and telomere length in east London schoolchildren: An observational study},
url = {http://dx.doi.org/10.1016/j.envint.2016.08.021},
volume = {96},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Short telomeres are associated with chronic disease and early mortality. Recent studies in adults suggest an association between telomere length and exposure to particulate matter, and that ethnicity may modify the relationship. However associations in children are unknown. OBJECTIVES: We examined associations between air pollution and telomere length in an ethnically diverse group of children exposed to high levels of traffic derived pollutants, particularly diesel exhaust, and to environmental tobacco smoke. METHODS: Oral DNA from 333 children (8-9years) participating in a study on air quality and respiratory health in 23 inner city London schools was analysed for relative telomere length using monochrome multiplex qPCR. Annual, weekly and daily exposures to nitrogen oxides and particulate matter were obtained from urban dispersion models (2008-10) and tobacco smoke by urinary cotinine. Ethnicity was assessed by self-report and continental ancestry by analysis of 28 random genomic markers. We used linear mixed effects models to examine associations with telomere length. RESULTS: Telomere length increased with increasing annual exposure to NOx (model coefficient 0.003, [0.001, 0.005], p<0.001), NO2 (0.009 [0.004, 0.015], p<0.001), PM2.5 (0.041, [0.020, 0.063], p<0.001) and PM10 (0.096, [0.044, 0.149], p<0.001). There was no association with environmental tobacco smoke. Telomere length was increased in children reporting black ethnicity (22% [95% CI 10%, 36%], p<0.001) CONCLUSIONS: Pollution exposure is associated with longer telomeres in children and genetic ancestry is an important determinant of telomere length. Further studies should investigate both short and long-term associations between pollutant exposure and telomeres in childhood and assess underlying mechanisms.
AU  - Walton,RT
AU  - Mudway,IS
AU  - Dundas,I
AU  - Marlin,N
AU  - Koh,LC
AU  - Aitlhadj,L
AU  - Vulliamy,T
AU  - Jamaludin,JB
AU  - Wood,HE
AU  - Barratt,BM
AU  - Beevers,S
AU  - Dajnak,D
AU  - Sheikh,A
AU  - Kelly,FJ
AU  - Griffiths,CJ
AU  - Grigg,J
DO  - 10.1016/j.envint.2016.08.021
EP  - 47
PY  - 2016///
SN  - 1873-6750
SP  - 41
TI  - Air pollution, ethnicity and telomere length in east London schoolchildren: An observational study
T2  - Environ Int
UR  - http://dx.doi.org/10.1016/j.envint.2016.08.021
UR  - https://www.ncbi.nlm.nih.gov/pubmed/27591803
UR  - https://www.sciencedirect.com/science/article/pii/S0160412016303191?via%3Dihub
VL  - 96
ER  -
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