Summary
Daniel M Davis, PhD, is a Visiting Professor at Imperial College London and is also The Director of Research in the Manchester Collaborative Centre for Inflammation Research - a research institute funded by the University of Manchester, AstraZeneca and GSK.
Prior to this, he was a Professor of Molecular Immunology at Imperial College London, UK and Head of the Immunology and Infection Section at the South Kensington Campus. He previously completed an Irvington Institute Postdoctoral Fellowship with Professor Jack Strominger at Harvard University, Cambridge, MA, USA, after earning a PhD in Physics at Strathclyde University, Glasgow, UK, and a BSc in Physics at the University of Manchester, UK.
Professor Davis pioneered the use of novel imaging techniques to help visualize key molecular components of the immune response. His work helped establish new concept of how immune cells communicate with each other and how they recognize disease. In 1999, he published the first images showing protein reorganisation at the interface between human Natural Killer (NK) cells and tumour cells. Exploring how changes in the arrangements of proteins occur and how they control communication between immune cells established the concept of the immune synapse, now recognised for its critical importance in cell communication and viral transfer between cells. His group recently described long membrane tethers or ‘nanotubes’ as a new class of physical connectors between immune cells ,which have now been visualised in vivo as well as in vitro. Such membrane nanotubes aid immune cell activity and present a novel direct route for HIV-1 to efficiently spread between T cells. Professor Davis has published over 100 papers, collectively cited more than 6000 times, and was the recipient of a Lister Prize Fellowship in 2005, a Wolfson Royal Society Merit Award in 2008 and became a Fellow of the Academy of Medical Sciences in 2011. He has authored many articles for a general audience, has presented several, well-received public lectures, and has written a popular-level science book – The Compatibility Gene - published by Penguin in 2013.
For a full description, please see our lab web page at: http://www.davislab.ls.manchester.ac.uk/
Selected Publications
Journal Articles
Bonavita E, Bromley CP, Jonsson G, et al., 2020, Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade, Immunity, Vol:53, ISSN:1074-7613, Pages:1215-+
Ambrose AR, Hazime KS, Worboys JD, et al., 2020, Synaptic secretion from human natural killer cells is diverse and includes supramolecular attack particles, Proceedings of the National Academy of Sciences of the United States of America, Vol:117, ISSN:0027-8424, Pages:23717-23720
Smith SL, Kennedy PR, Stacey KB, et al., 2020, Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing, Blood Advances, Vol:4, ISSN:2473-9529, Pages:1388-1406
Kennedy PR, Barthen C, Williamson DJ, et al., 2019, Genetic diversity affects the nanoscale membrane organization and signaling of natural killer cell receptors, Science Signaling, Vol:12, ISSN:1945-0877
Srpan K, Ambrose A, Karampatzakis A, et al., 2018, Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells, Journal of Cell Biology, Vol:217, ISSN:0021-9525, Pages:3267-3283
Balint S, Lopes FB, Davis DM, 2018, A nanoscale reorganization of the IL-15 receptor is triggered by NKG2D in a ligand-dependent manner, Science Signaling, Vol:11, ISSN:1945-0877
Brown ACN, Dobbie IM, Alakoskela J-M, et al., 2012, Super-resolution imaging of remodeled synaptic actin reveals different synergies between NK cell receptors and integrins, Blood, Vol:120, ISSN:0006-4971, Pages:3729-3740
Brown ACN, Oddos S, Dobbie IM, et al., 2011, Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy, PLOS Biology, Vol:9, ISSN:1544-9173, Pages:1-18
Chauveau A, Aucher A, Eissmann P, et al., 2010, Membrane nanotubes facilitate long-distance interactions between natural killer cells and target cells, Proceedings of the National Academy of Sciences of the United States of America, Vol:107, ISSN:0027-8424, Pages:5545-5550
Davis DM, 2009, Mechanisms and functions for the duration of intercellular contacts made by lymphocytes, Nature Reviews Immunology, Vol:9, ISSN:1474-1733, Pages:543-555
Culley FJ, Johnson M, Evans JH, et al., 2009, Natural Killer Cell Signal Integration Balances Synapse Symmetry and Migration, PLOS Biology, Vol:7, ISSN:1544-9173
Davis DM, Sowinski S, 2008, Membrane nanotubes: dynamic long-distance connections between animal cells, Nature Reviews Molecular Cell Biology, Vol:9, ISSN:1471-0072, Pages:431-436
Sowinski S, Jolly C, Berninghausen O, et al., 2008, Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission, Nature Cell Biology, Vol:10, ISSN:1465-7392, Pages:211-219
Nedvetzki S, Sowinski S, Eagle RA, et al., 2007, Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses, Blood, Vol:109, ISSN:0006-4971, Pages:3776-3785
McCann FE, Eissmann P, Onfelt B, et al., 2007, The activating NKG2D ligand MHC class I-related chain a transfers from target cells to NK cells in a manner that allows functional consequences, Journal of Immunology, Vol:178, ISSN:0022-1767, Pages:3418-3426
Davis DM, 2007, Intercellular transfer of cell-surface proteins is common and can affect many stages of an immune response, Nature Reviews Immunology, Vol:7, ISSN:1474-1733, Pages:238-243
Nolte-'t Hoen ENM, Almeida CR, Cohen NR, et al., 2007, Increased surveillance of cells in mitosis by human NK cells suggests a novel strategy for limiting tumor growth and viral replication, Blood, Vol:109, ISSN:0006-4971, Pages:670-673
Onfelt B, Nedvetzki S, Benninger RKP, et al., 2006, Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria, Journal of Immunology, Vol:177, ISSN:0022-1767, Pages:8476-8483
Treanor B, Lanigan PMP, Kumar S, et al., 2006, Microclusters of inhibitory killer immunoglobulin like receptor signaling at natural killer cell immunological synapses, Journal of Cell Biology, Vol:174, ISSN:1540-8140, Pages:153-161
Davis DM, 2006, Intrigue at the immune synapse, Scientific American, Vol:294, ISSN:0036-8733, Pages:48-55
Vanherberghen B, Andersson K, Carlin LM, et al., 2004, Human and murine inhibitory natural killer cell receptors transfer from natural killer cells to target cells, Proceedings of the National Academy of Sciences of the United States of America, Vol:101, ISSN:0027-8424, Pages:16873-16878
Onfelt B, Nedvetzki S, Yanagi K, et al., 2004, Cutting edge: Membrane nanotubes connect immune cells, Journal of Immunology, Vol:173, ISSN:0022-1767, Pages:1511-1513
Davis DM, Dustin ML, 2004, What is the importance of the immunological synapse?, Trends in Immunology, Vol:25, ISSN:1471-4906, Pages:323-327
Eleme K, Taner SB, Onfelt B, et al., 2004, Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D, Journal of Experimental Medicine, Vol:199, ISSN:0022-1007, Pages:1005-1010
Carlin LM, Eleme K, McCann FE, et al., 2001, Intercellular transfer and supramolecular organization of human leukocyte antigen C at inhibitory natural killer cell immune synapses, Journal of Experimental Medicine, Vol:194, ISSN:0022-1007, Pages:1507-1517
Davis DM, Chiu I, Fassett M, et al., 1999, The human natural killer cell immune synapse, Proceedings of the National Academy of Sciences of the United States of America, Vol:96, ISSN:0027-8424, Pages:15062-15067
MAndelboim O, Davis DM, Reyburn HT, et al., 1996, Enhancement of class II-restricted T cell responses by costimulatory NK receptors for class I MHC proteins, Science, Vol:274, ISSN:0036-8075, Pages:2097-2100
Conference
Carisey AF, Mace EM, Saeed MB, et al., 2017, Nanoscale dynamism of F-actin enables secretory function in cytolytic cells., Annual Joint Meeting of the American-Society-for-Cell-Biology and the European-Molecular-Biology-Organization (ASCB/EMBO), AMER SOC CELL BIOLOGY, ISSN:1059-1524