Imperial College London
Portrait Picture

ProfessorDanielDavis

Faculty of Natural Sciences, Department of Life Sciences

Head of Department of Life Sciences, Chair in Immunology
 
 
 
//

Contact

 

+44 (0)20 7594 5420d.davis CV

 
 
//

Location

 

609Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Tuomela:2022:10.3389/fimmu.2022.867098,
author = {Tuomela, K and Ambrose, AR and Davis, DM},
doi = {10.3389/fimmu.2022.867098},
journal = {Frontiers in Immunology},
title = {Escaping death: how cancer cells and infected cells resist cell-mediated cytotoxicity},
url = {http://dx.doi.org/10.3389/fimmu.2022.867098},
volume = {13},
year = {2022}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cytotoxic lymphocytes are critical in our immune defence against cancer and infection. Cytotoxic T lymphocytes and Natural Killer cells can directly lyse malignant or infected cells in at least two ways: granule-mediated cytotoxicity, involving perforin and granzyme B, or death receptor-mediated cytotoxicity, involving the death receptor ligands, tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas ligand (FasL). In either case, a multi-step pathway is triggered to facilitate lysis, relying on active pro-death processes and signalling within the target cell. Because of this reliance on an active response from the target cell, each mechanism of cell-mediated killing can be manipulated by malignant and infected cells to evade cytolytic death. Here, we review the mechanisms of cell-mediated cytotoxicity and examine how cells may evade these cytolytic processes. This includes resistance to perforin through degradation or reduced pore formation, resistance to granzyme B through inhibition or autophagy, and resistance to death receptors through inhibition of downstream signalling or changes in protein expression. We also consider the importance of tumour necrosis factor (TNF)-induced cytotoxicity and resistance mechanisms against this pathway. Altogether, it is clear that target cells are not passive bystanders to cell-mediated cytotoxicity and resistance mechanisms can significantly constrain immune cell-mediated killing. Understanding these processes of immune evasion may lead to novel ideas for medical intervention.
AU  - Tuomela,K
AU  - Ambrose,AR
AU  - Davis,DM
DO  - 10.3389/fimmu.2022.867098
PY  - 2022///
SN  - 1664-3224
TI  - Escaping death: how cancer cells and infected cells resist cell-mediated cytotoxicity
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2022.867098
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35401556
UR  - http://hdl.handle.net/10044/1/96609
VL  - 13
ER  -
Download