Imperial College London
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ProfessorDanielDavis

Faculty of Natural Sciences, Department of Life Sciences

Head of Department of Life Sciences, Chair in Immunology
 
 
 
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Contact

 

+44 (0)20 7594 5420d.davis CV

 
 
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Location

 

609Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Webb:2017:10.15252/embj.201695345,
author = {Webb, LM and Lundie, RJ and Borger, JG and Brown, SL and Connor, LM and Cartwright, ANR and Dougall, AM and Wilbers, RHP and Cook, PC and Jackson-Jones, LH and Phythian-Adams, AT and Johansson, C and Davis, DM and Dewals, BG and Ronchese, F and MacDonald, AS},
doi = {10.15252/embj.201695345},
journal = {EMBO JOURNAL},
pages = {2404--2418},
title = {Type I interferon is required for T helper (Th) 2 induction by dendritic cells},
url = {http://dx.doi.org/10.15252/embj.201695345},
volume = {36},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Type 2 inflammation is a defining feature of infection with parasitic worms (helminths), as well as being responsible for widespread suffering in allergies. However, the precise mechanisms involved in T helper (Th) 2 polarization by dendritic cells (DCs) are currently unclear. We have identified a previously unrecognized role for type I IFN (IFNI) in enabling this process. An IFNI signature was evident in DCs responding to the helminth Schistosoma mansoni or the allergen house dust mite (HDM). Further, IFNI signaling was required for optimal DC phenotypic activation in response to helminth antigen (Ag), and efficient migration to, and localization with, T cells in the draining lymph node (dLN). Importantly, DCs generated from Ifnar1−/− mice were incapable of initiating Th2 responses in vivo. These data demonstrate for the first time that the influence of IFNI is not limited to antiviral or bacterial settings but also has a central role to play in DC initiation of Th2 responses.
AU  - Webb,LM
AU  - Lundie,RJ
AU  - Borger,JG
AU  - Brown,SL
AU  - Connor,LM
AU  - Cartwright,ANR
AU  - Dougall,AM
AU  - Wilbers,RHP
AU  - Cook,PC
AU  - Jackson-Jones,LH
AU  - Phythian-Adams,AT
AU  - Johansson,C
AU  - Davis,DM
AU  - Dewals,BG
AU  - Ronchese,F
AU  - MacDonald,AS
DO  - 10.15252/embj.201695345
EP  - 2418
PY  - 2017///
SN  - 0261-4189
SP  - 2404
TI  - Type I interferon is required for T helper (Th) 2 induction by dendritic cells
T2  - EMBO JOURNAL
UR  - http://dx.doi.org/10.15252/embj.201695345
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000407786500009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/51755
VL  - 36
ER  -
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